ArticleMagnetic resonance in medicine2014
Intracellular redox state revealed by in vivo (31) P MRS measurement of NAD(+) and NADH contents in brains.
Article in Magnetic resonance in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 65 citations in OpenAlex.
- Development of aNature communications · 2024Trial
- In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences.Proceedings of the National Academy of Sciences of the United States of America · 2015Trial
- Metabolic and Volumetric Alterations in the Basal Ganglia and the Cerebellum in Dopa-Responsive Dystonia in Symptomatic and Asymptomatic GCH1 Mutation Carriers.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- MRS and Optical Imaging Studies of Therapeutic Response to Combination Therapy Targeting BRAF/MEK in Murine Melanomas.Academic radiology · 2026Article
- The role of the gut microbiota and the nicotinate/nicotinamide pathway in rotenone-induced neurotoxicity.Current research in toxicology · 2025Article
- Acute nicotinamide riboside supplementation increases human cerebral NADMagnetic resonance in medicine · 2024Article
- Mapping intracellular NAD content in entire human brain using phosphorus-31 MR spectroscopic imaging at 7 Tesla.Frontiers in neuroscience · 2024Article
- Nicotinamide Adenine Dinucleotide in Aging Biology: Potential Applications and Many Unknowns.Endocrine reviews · 2023Review
- ATP and NADNutrients · 2023Article
- Quantification of NADMagnetic resonance in medicine · 2022Article
- Neuroimaging Methods to Map In Vivo Changes of OXPHOS and Oxidative Stress in Neurodegenerative Disorders.International journal of molecular sciences · 2022Review
- Mitochondrial Respiratory Chain Dysfunction-A Hallmark Pathology of Idiopathic Parkinson's Disease?Frontiers in cell and developmental biology · 2022Article
- Assessment of Nicotinamide Adenine Dinucleotide in Human Tissues by In Vivo Phosphorus-31 Magnetic Resonance Spectroscopic Imaging at 1.5 Tesla.Advances in experimental medicine and biology · 2022Article
- Feasibility of Non-invasive Measurement of Tumour NAD(H) by In Vivo Phosphorus-31 Magnetic Resonance Spectroscopy.Advances in experimental medicine and biology · 2022Article
- In VitroMolecules (Basel, Switzerland) · 2021Article
- Co-Polarized [1-ACS sensors · 2021Article
- 3DNMR in biomedicine · 2021Article
- Quantitative Assessment of Occipital Metabolic and Energetic Changes in Parkinson's Patients, Using In VivoMetabolites · 2021Article
- Cerebral phosphoester signals measured by 31P magnetic resonance spectroscopy at 3 and 7 Tesla.PloS one · 2021Article
- Mapping an Extended Metabolic Profile of Gliomas Using High-ResolutionFrontiers in neurology · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
purposeNicotinamide adenine dinucleotide (NAD), in oxidized (NAD(+) ) or reduced (NADH) form, plays key roles in cellular metabolism. Intracellular NAD(+) /NADH ratio represents the cellular redox state; however, it is difficult to measure in vivo. We report here a novel in vivo (31) P MRS method for noninvasive measurement of intracellular NAD concentrations and NAD(+) /NADH ratio in the brain.
methodsIt uses a theoretical model to describe the NAD spectral patterns at a given field for quantification. Standard NAD solutions and independent cat brain measurements at 9.4 T and 16.4 T were used to evaluate this method. We also measured T1 values of brain NAD.
resultsModel simulation and studies of solutions and brains indicate that the proposed method can quantify submillimolar NAD concentrations with reasonable accuracy if adequate (31) P MRS signal-to-noise ratio and linewidth were obtained. The NAD concentrations and NAD(+) /NADH ratio of cat brains measured at 16.4 T and 9.4 T were consistent despite the significantly different T1 values and NAD spectra patterns at two fields.
conclusionThis newly established (31) P MRS method makes it possible for the first time to noninvasively study the intracellular redox state and its roles in brain functions and diseases, and it can potentially be applied to other organs.
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