ReviewWiley interdisciplinary reviews. Systems biology and medicine
Multiscale image-based modeling and simulation of gas flow and particle transport in the human lungs.
Review in Wiley interdisciplinary reviews. Systems biology and medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 82 citations in OpenAlex.
- CFD Modeling of Airflow and Aerosol Transport in the Human Respiratory System: A Comprehensive Review.Pharmaceutical research · 2026Review
- Human lungs fluid mechanics: an overview of current modelling techniques.The European physical journal. E, Soft matter · 2026Review
- How Does Biological Sex Impact Mucosal Bacterial Infection? Mucosal Defenses and Bacterial Detection.Immunological reviews · 2026Review
- Sex disparities in cystic fibrosis in the era of highly effective modulator treatment.BMC pulmonary medicine · 2025Review
- Forward Computational Modeling of Respiratory Airflow.Applied sciences (Basel, Switzerland) · 2024Article
- Investigating distributions of inhaled aerosols in the lungs of post-COVID-19 clusters through a unified imaging and modeling approach.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2024Article
- Insights from 3D modeling and fluid dynamics in COVID-19 pneumonia.Medical & biological engineering & computing · 2024Article
- Origins of and lessons from quantitative functional X-ray computed tomography of the lung.The British journal of radiology · 2022Review
- CT-derived 3D-diaphragm motion in emphysema and IPF compared to normal subjects.Scientific reports · 2021Article
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- A Review of Respiratory Anatomical Development, Air Flow Characterization and Particle Deposition.International journal of environmental research and public health · 2020Review
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- Structural and functional alterations of the tracheobronchial tree after left upper pulmonary lobectomy for lung cancer.Biomedical engineering online · 2019Article
- In Silico Methods for Development of Generic Drug-Device Combination Orally Inhaled Drug Products.CPT: pharmacometrics & systems pharmacology · 2019Review
- Use of computational fluid dynamics deposition modeling in respiratory drug delivery.Expert opinion on drug delivery · 2019Review
- Biomimetics of the pulmonary environmentBiomicrofluidics · 2018Article
- Particle Disposition in the Realistic Airway Tree Models of Subjects with Tracheal Bronchus and COPD.BioMed research international · 2018Article
- Substance deposition assessment in obstructed pulmonary system through numerical characterization of airflow and inhaled particles attributes.BMC medical informatics and decision making · 2017Article
- Automatic construction of subject-specific human airway geometry including trifurcations based on a CT-segmented airway skeleton and surface.Biomechanics and modeling in mechanobiology · 2017Article
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Improved understanding of structure and function relationships in the human lungs in individuals and subpopulations is fundamentally important to the future of pulmonary medicine. Image-based measures of the lungs can provide sensitive indicators of localized features, however to provide a better prediction of lung response to disease, treatment, and environment, it is desirable to integrate quantifiable regional features from imaging with associated value-added high-level modeling. With this objective in mind, recent advances in computational fluid dynamics (CFD) of the bronchial airways-from a single bifurcation symmetric model to a multiscale image-based subject-specific lung model-will be reviewed. The interaction of CFD models with local parenchymal tissue expansion-assessed by image registration-allows new understanding of the interplay between environment, hot spots where inhaled aerosols could accumulate, and inflammation. To bridge ventilation function with image-derived central airway structure in CFD, an airway geometrical modeling method that spans from the model 'entrance' to the terminal bronchioles will be introduced. Finally, the effects of turbulent flows and CFD turbulence models on aerosol transport and deposition will be discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.