ArticleGenome biology and evolution2013
A broad genomic survey reveals multiple origins and frequent losses in the evolution of respiratory hemerythrins and hemocyanins.
Article in Genome biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Oxygen-binding proteins aid oxygen diffusion to enhance fitness of a yeast model of multicellularity.PLoS biology · 2025Article
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- Respiratory protein-driven selectivity during the Permian-Triassic mass extinction.Innovation (Cambridge (Mass.)) · 2024Article
- Examining the role of oxygen-binding proteins on the early evolution of multicellularity.bioRxiv : the preprint server for biology · 2023Article
- Glyphosate inhibits melanization and increases susceptibility to infection in insects.PLoS biology · 2021Article
- Globins in the marine annelid Platynereis dumerilii shed new light on hemoglobin evolution in bilaterians.BMC evolutionary biology · 2020Article
- Evolutionary History of the Globin Gene Family in Annelids.Genome biology and evolution · 2020Article
- Neoproterozoic copper cycling, and the rise of metazoans.Scientific reports · 2019Article
- Newly Discovered Occurrences and Gene Tree of the Extracellular Globins and Linker Chains from the Giant Hexagonal Bilayer Hemoglobin in Metazoans.Genome biology and evolution · 2019Article
- Diversity, evolution, and function of myriapod hemocyanins.BMC evolutionary biology · 2018Article
- Structure, function and evolution of the hemerythrin-like domain superfamily.Protein science : a publication of the Protein Society · 2018Article
- Broad Phylogenetic Occurrence of the Oxygen-Binding Hemerythrins in Bilaterians.Genome biology and evolution · 2017Article
- Discovery and evolution of novel hemerythrin genes in annelid worms.BMC evolutionary biology · 2017Article
- Diversity and Evolutionary Analysis of Iron-Containing (Type-III) Alcohol Dehydrogenases in Eukaryotes.PloS one · 2016Article
- Article
- Differential roles of the hemerythrin-like proteins of Mycobacterium smegmatis in hydrogen peroxide and erythromycin susceptibility.Scientific reports · 2015Article
- The dual nature of haemocyanin in the establishment and persistence of the squid-vibrio symbiosis.Proceedings. Biological sciences · 2014Article
- A bacterial hemerythrin-like protein MsmHr inhibits the SigF-dependent hydrogen peroxide response in mycobacteria.Frontiers in microbiology · 2014Article
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Hemerythrins and hemocyanins are respiratory proteins present in some of the most ecologically diverse animal lineages; however, the precise evolutionary history of their enzymatic domains (hemerythrin, hemocyanin M, and tyrosinase) is still not well understood. We survey a wide dataset of prokaryote and eukaryote genomes and RNAseq data to reconstruct the phylogenetic origins of these proteins. We identify new species with hemerythrin, hemocyanin M, and tyrosinase domains in their genomes, particularly within animals, and demonstrate that the current distribution of respiratory proteins is due to several events of lateral gene transfer and/or massive gene loss. We conclude that the last common metazoan ancestor had at least two hemerythrin domains, one hemocyanin M domain, and six tyrosinase domains. The patchy distribution of these proteins among animal lineages can be partially explained by physiological adaptations, making these genes good targets for investigations into the interplay between genomic evolution and physiological constraints.
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