ArticleJournal of magnetic resonance imaging : JMRI2014
Diffusion tensor MRI of the corpus callosum in amyotrophic lateral sclerosis.
Article in Journal of magnetic resonance imaging : JMRI, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- The value of magnetic resonance imaging as a biomarker for amyotrophic lateral sclerosis: a systematic review.BMC neurology · 2016Pooled it
- Superficial white matter microstructural impairments correlate with functional alterations and disease severity in early-stage amyotrophic lateral sclerosis.La Radiologia medica · 2026Article
- Impairment of brain short association fibers across clinical stages in amyotrophic lateral sclerosis: a new biomarker mirroring disease progression.BMC medicine · 2026Article
- Mapping motor and extra-motor gray and white matter changes in ALS: a comprehensive review of MRI insights.Neuroradiology · 2025Review
- Reduced beta bursting underpins loss of corticomuscular coherence in amyotrophic lateral sclerosis.Brain communications · 2025Article
- Characterization of white matter alterations using diffusion kurtosis imaging in patients with amyotrophic lateral sclerosis.Brain and behavior · 2023Article
- Neuroimaging in Breast Implant Illness: An fMRI Pilot Study.Aesthetic surgery journal · 2023Article
- Longitudinal surface-based spatial Bayesian GLM reveals complex trajectories of motor neurodegeneration in ALS.NeuroImage · 2022Article
- Alterations of Microstructure and Sodium Homeostasis in Fast Amyotrophic Lateral Sclerosis Progressors: A Brain DTI and Sodium MRI Study.AJNR. American journal of neuroradiology · 2022Article
- Article
- Segmental involvement of the corpus callosum inTherapeutic advances in chronic disease · 2021Article
- Focal alterations of the callosal area III in primary lateral sclerosis: An MRI planimetry and texture analysis.NeuroImage. Clinical · 2020Article
- Investigation of Neurodegenerative Processes in Amyotrophic Lateral Sclerosis Using White Matter Fiber Density.Clinical neuroradiology · 2019Article
- Radial diffusivity as an imaging biomarker for early diagnosis of non-demented amyotrophic lateral sclerosis.European radiology · 2018Article
- Transcallosal connectivity of the human cortical motor network.Brain structure & function · 2017Article
- Neuroimaging Endpoints in Amyotrophic Lateral Sclerosis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017Review
- ALS biomarkers for therapy development: State of the field and future directions.Muscle & nerve · 2016Review
- Assessing Microstructural Substrates of White Matter Abnormalities: A Comparative Study Using DTI and NODDI.PloS one · 2016Article
- Interhemispheric connectivity in amyotrophic lateral sclerosis: A near-infrared spectroscopy and diffusion tensor imaging study.NeuroImage. Clinical · 2016Article
- Neuroimaging as a New Diagnostic Modality in Amyotrophic Lateral Sclerosis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2015Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo determine if decline in corpus callosum (CC) white matter integrity in patients with amyotrophic lateral sclerosis (ALS) is localized to motor-related areas. MATERIALS AND
methodsTwenty-one ALS patients and 21 controls participated. Diffusion tensor images (DTI) were acquired using 3 Tesla (T) MRI. Tract-based spatial statistics were used to examine whole-brain white matter damage. A segmentation schema was used to define CC volumes-of-interest (VOI). Fractional anisotropy (FA) and radial- and axial-diffusivity (RD, AD) were extracted from VOIs and compared between groups. DTI measurements in motor-related Area III were tested for correlation with symptoms and disease duration.
resultsExtracted FA values from CC VOIs were reduced in ALS patients (P≤0.0001), particularly in Areas II and III (P≤0.01). Reduced FA in Area III correlated with disease symptomology (P≤0.05) and duration (P≤0.02). Between-group whole-brain comparisons (P≤0.05, corrected) showed reduced FA and increased RD throughout white matter regions including the CC, corona radiata, and internal capsule. AD was increased in the left corona radiata and internal and external capsules.
conclusionFA in motor-related regions of the CC is more affected than other CC areas in ALS patients. Microstructural pathology of transcallosal fiber tracts may represent a future component of an imaging biomarker for ALS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.