ReviewPediatric radiology2013
Safety of contrast-enhanced ultrasound in children for non-cardiac applications: a review by the Society for Pediatric Radiology (SPR) and the International Contrast Ultrasound Society (ICUS).
Review in Pediatric radiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 59 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Use of Intraoperative Contrast-enhanced Ultrasound to Evaluate Femoral Head Perfusion in Infants With Developmental Dysplasia of the Hip at the Time of Surgical Reduction
Contrast Enhanced Ultrasonography for Blunt Abdominal Trauma Imaging in Children
Who cites it
59 citing papers in PubMed, 3 syntheses or guidelines pooled it, 128 citations in OpenAlex.
- Contrast-enhanced ultrasound in pediatric blunt abdominal trauma: a systematic review.Journal of ultrasound · 2022Pooled it
- European Society of Paediatric Radiology abdominal imaging task force: recommendations for contrast-enhanced ultrasound and diffusion-weighted imaging in focal renal lesions in children.Pediatric radiology · 2020Guideline
- ESPR uroradiology task force imaging recommendations in paediatric uroradiology, part VII: standardised terminology, impact of existing recommendations, and update on contrast-enhanced ultrasound of the paediatric urogenital tract.Pediatric radiology · 2014Guideline
- Evaluation of hepatic infantile hemangiomas: the potential of contrast-enhanced ultrasound.Frontiers in cardiovascular medicine · 2026Article
- Standardizing Safety Practices for Contrast-Enhanced Ultrasound in Radiology.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Article
- A Comparison of Contrast-Enhanced Voiding Urosonography (CE-VUS) and Contrast Retrograde Cystourethrography (RCUG) for the Detection of Vesicoureteral Reflux in Young Dogs.Animals : an open access journal from MDPI · 2025Article
- Contrast-enhanced ultrasonography (CEUS) in the management of pediatric renal injuries: where are we now?Journal of ultrasound · 2025Article
- Contrast-enhanced ultrasound for differentiation of gallbladder sludge from polyp: A case report demonstrating clinical utility.Radiology case reports · 2025Article
- Delivery of Cavitation Therapy With a Modified Clinical Scanner: In Vitro Evaluation.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2025Article
- Multi-societal expert consensus statement on the safe administration of ultrasound contrast agents.Echo research and practice · 2025Review
- Contrast-enhanced ultrasound for differentiating benign from malignant focal solid renal lesions in pediatric patients.Scientific reports · 2024Article
- Contrast enhanced ultrasound of cystic renal lesions, from diagnosis up to treatment.Clinical hemorheology and microcirculation · 2024Review
- Review on Pediatric Malignant Focal Liver Lesions with Imaging Evaluation: Part I.Diagnostics (Basel, Switzerland) · 2023Review
- Controlled Hyperthermia With High-Intensity Focused Ultrasound and Ultrasound Contrast Agent Microbubbles in Porcine Liver.Ultrasound in medicine & biology · 2023Article
- The Utility of Contrast Enhanced Ultrasound and Elastography in the Early Detection of Fibro-Stenotic Ileal Strictures in Children with Crohn's Disease.Pediatric gastroenterology, hepatology & nutrition · 2023Article
- Transtemporal brain contrast-enhanced ultrasound in children: preliminary experience in patients without neurological disorders.Journal of ultrasound · 2023Article
- A narrative review on the applications of intracavitary contrast-enhanced ultrasonography in pediatric lower genitourinary anomalies.Frontiers in pediatrics · 2023Review
- Fluorescence-Guided Surgery and Novel Innovative Technologies for Improved Visualization in Pediatric Urology.International journal of environmental research and public health · 2022Review
- Ultrasound imaging of preterm brain injury: fundamentals and updates.Pediatric radiology · 2022Review
- Contrast-enhanced ultrasound of the neonatal brain.Pediatric radiology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 11 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The practice of contrast-enhanced ultrasound in children is in the setting of off-label use or research. The widespread practice of pediatric contrast-enhanced US is primarily in Europe. There is ongoing effort by the Society for Pediatric Radiology (SPR) and International Contrast Ultrasound Society (ICUS) to push for pediatric contrast-enhanced US in the United States. With this in mind, the main objective of this review is to describe the status of US contrast agent safety in non-cardiac applications in children. The five published studies using pediatric intravenous contrast-enhanced US comprise 110 children. There is no mention of adverse events in these studies. From a European survey 948 children can be added. In that survey six minor adverse events were reported in five children. The intravesical administration of US contrast agents for diagnosis of vesicoureteric reflux entails the use of a bladder catheter. Fifteen studies encompassing 2,951 children have evaluated the safety of intravesical US contrast agents in children. A European survey adds 4,131 children to this group. No adverse events could be attributed to the contrast agent. They were most likely related to the bladder catheterization. The existing data on US contrast agent safety in children are encouraging in promoting the widespread use of contrast-enhanced US.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.