ReviewJournal of assisted reproduction and genetics2013
Could time-lapse embryo imaging reduce the need for biopsy and PGS?
Review in Journal of assisted reproduction and genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Can Comprehensive Chromosome Screening Technology Improve IVF/ICSI Outcomes? A Meta-Analysis.PloS one · 2015Pooled it
- Non-invasive embryo assessment: Cell-free DNA-based genetic testing and amino acid metabolomics in relation to morphology: A case-control study.International journal of reproductive biomedicine · 2026Article
- Prediction of blastocyst development using cleavage-stage embryo metrics and maternal age.Scientific reports · 2025Article
- Non-Invasive Preimplantation Genetic Testing.Genes · 2025Review
- Novel Time-Lapse Parameters Correlate with Embryo Ploidy and Suggest an Improvement in Non-Invasive Embryo Selection.Journal of clinical medicine · 2023Article
- The use of voting ensembles to improve the accuracy of deep neural networks as a non-invasive method to predict embryo ploidy status.Journal of assisted reproduction and genetics · 2023Article
- Blastulation time measured with time-lapse system can predict in vitro viability of bovine blastocysts.PloS one · 2023Article
- Time-Lapse Embryo culture: A better understanding of embryo development and clinical application.JBRA assisted reproduction · 2022Review
- Pseudo contrastive labeling for predicting IVF embryo developmental potential.Scientific reports · 2022Article
- Assessing the impact of delayed blastulation using time lapse morphokinetics and preimplantation genetic testing in an IVF patient population.Journal of assisted reproduction and genetics · 2019Article
- Impact of polar body biopsy on embryo morphokinetics-back to the roots in preimplantation genetic testing?Journal of assisted reproduction and genetics · 2018Article
- Clinical reassessment of human embryo ploidy status between cleavage and blastocyst stage by Next Generation Sequencing.PloS one · 2018Article
- Morphokinetic parameters from a time-lapse monitoring system cannot accurately predict the ploidy of embryos.Journal of assisted reproduction and genetics · 2017Article
- Association between growth dynamics, morphological parameters, the chromosomal status of the blastocysts, and clinical outcomes in IVF PGS cycles with single embryo transfer.Journal of assisted reproduction and genetics · 2017Article
- Recent advances in preimplantation genetic diagnosis and screening.Journal of assisted reproduction and genetics · 2016Review
- Morphokinetic Evaluation of Embryo Development in a Mouse Model: Functional and Molecular Correlates.Biology of reproduction · 2016Article
- Morphokinetic parameters of early embryo development via time lapse monitoring and their effect on embryo selection and ICSI outcomes: a prospective cohort study.Journal of assisted reproduction and genetics · 2015Article
- Early Morphokinetic Monitoring of Embryos after Intracytoplasmic Sperm Injection with Fresh Ejaculate Sperm in Nonmosaic Klinefelter Syndrome: A Different Presentation.Case reports in genetics · 2015Article
- Analysis of embryo morphokinetics, multinucleation and cleavage anomalies using continuous time-lapse monitoring in blastocyst transfer cycles.Reproductive biology and endocrinology : RB&E · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo review relevant studies examining the relationship between embryo morpho-kinetics and aneuploidy.
methodsSearch of Pubmed and Medline using relevant keywords pertaining to morphology, morphokinetics and embryonic aneuploidy, as well as examination of various reference lists and conference proceedings.
resultsAn abundance of publications, both preliminary and peer-reviewed, have emerged regarding the usefulness of time-lapse imaging in tracking embryo development and improving embryo selection. Recently, these publications have explored ability to not only predict blastocyst formation and implantation, but also the ability to detect embryonic chromosomal aneuploidy. Of the two peer-reviewed retrospective studies on morpho-kinetics and embryonic aneuploidy, one demonstrates that early cleavage timings can indicate chromosomal complement, while the other demonstrates that key events following the maternal-zygotic transition can be markers of aneuploidy. A recent paper also demonstrates improved outcomes following IVF using a selection algorithm to identify embryos at "low risk" of chromosomal abnormalities. However, the predictive nature of these events and timings is far from ideal. Additionally, results may be dependent upon the day of biopsy and method utilized for chromosomal assessment.
conclusionWith continued effort, the combination of multiple morphologic endpoint assessments and developmental timings and refinement of modeling systems may improve the predictive ability to determine embryonic aneuploidy. This may help select a subset of embryos that are less likely to carry chromosomal abnormalities and improve assisted reproductive outcomes. However, embryo biopsy, followed by preimplantation genetic screening/comprehensive chromosomal screening still remains the most reliable method to assess chromosomal complement of preimplantation embryos.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.