Trial reportJournal of thrombosis and thrombolysis2014
Attenuation of spontaneous thrombolytic activity measured by the global thrombosis test in male habitual smokers.
Trial report in Journal of thrombosis and thrombolysis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Global Thrombosis Test: Occlusion Is Attributable to Shear-Induced Platelet Thrombus Formation.TH open : companion journal to thrombosis and haemostasis · 2021Article
- Global Thrombosis Test: Occlusion by Coagulation or SIPA?TH open : companion journal to thrombosis and haemostasis · 2021Article
- Role, Laboratory Assessment and Clinical Relevance of Fibrin, Factor XIII and Endogenous Fibrinolysis in Arterial and Venous Thrombosis.International journal of molecular sciences · 2021Review
- Are all wines made from various grape varieties beneficial in the prevention of myocardial infarction and stroke?Future science OA · 2020Article
- Shear rate-dependent thrombosis/fibrinolysis tests using non-anticoagulated blood could be useful in the prevention of thrombotic disorders.Future science OA · 2019Article
- Prevention of thrombotic disorders by antithrombotic diet and exercise: evidence by using global thrombosis tests.Future science OA · 2018Review
- Importance of Endogenous Fibrinolysis in Platelet Thrombus Formation.International journal of molecular sciences · 2017Review
- Effect of exercise training on clot strength in patients with peripheral artery disease and intermittent claudication: An ancillary study.SAGE open medicine · 2015Article
- Enhanced pre-operative thrombolytic status is associated with the incidence of deep venous thrombosis in patients undergoing total knee arthroplasty.Thrombosis journal · 2014Article
- Measuring Thrombus Stability at High Shear, Together With Thrombus Formation and Endogenous Fibrinolysis: First Experience Using the Global Thrombosis Test 3 (GTT-3).Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Smoking is known as one of the major risk factors for atherothrombotic cardiovascular diseases. We investigated the susceptibility to thrombosis in habitual smokers by using the global thrombosis test (GTT), by which both clot formation and clot lysis activities can be evaluated simultaneously in native blood samples in vitro. Subjects were 139 men participating in a periodic health checkup examination, and an informed consent for the subjects was obtained as a document. Using GTT, occlusion time (OT: the time taken for clot formation in the blood sample) and lysis time (LT: the time taken for lysis of the clot that had been formed) were measured. LT was significantly (p = 0.029) longer in smokers [median with range, 1,794 (1,080-6,000) s (n = 76)] than in nonsmokers [median with range, 1,530 (792-3,800) s (n = 63)], while there was no significant difference in OT between smokers and nonsmokers. In smokers, LT was significantly correlated with daily cigarette consumption but not with Brinkman index. LT measured in nine smokers at 3 months after quitting their habitual smoking was significantly shorter than LT measured before the cessation of smoking. Since prolongation of LT implies existence of thrombogenic tendency, smokers are thought to be more susceptible to thrombosis due to decreased fibrinolytic activity, and no smoking for even a short term may be effective for improving fibrinolytic activity in smokers.
Indexed as
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Registered trials
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