ArticleEnvironmental health perspectives2013
Ambient ozone concentrations and the risk of perforated and nonperforated appendicitis: a multicity case-crossover study.
Article in Environmental health perspectives, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Trends in the global burden of appendicitis in children at global, regional, and national levels: An analysis using GBD 2021 data.The Journal of the Egyptian Public Health Association · 2026Article
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- Associations between Changes in Exposure to Air Pollutants due to Relocation and the Incidence of 14 Major Disease Categories and All-Cause Mortality: A Natural Experiment Study.Environmental health perspectives · 2024Article
- Exposure to air pollution and non-neoplastic digestive system diseases: findings from the China health and retirement longitudinal study.Frontiers in public health · 2024Article
- Impacts of short-term air pollution exposure on appendicitis admissions: Evidence from one of the most polluted cities in mainland China.Frontiers in public health · 2023Article
- Short-term effects of ambient air pollution on daily emergency room visits for abdominal pain: a time-series study in Wuhan, China.Environmental science and pollution research international · 2022Article
- Indoor Solid Fuel Use and Non-Neoplastic Digestive System Diseases: A Population-Based Cohort Study Among Chinese Middle-Aged and Older Population.International journal of public health · 2022Article
- The SARS-CoV-2 first wave impact in the acute inflammatory surgical pathologies.Scientific reports · 2021Article
- Exposure to air pollutants and the gut microbiota: a potential link between exposure, obesity, and type 2 diabetes.Gut microbes · 2020Review
- Ambient air pollution and cause-specific risk of hospital admission in China: A nationwide time-series study.PLoS medicine · 2020Article
- Exploring geographic variation in acute appendectomy in Ireland: results from a national registry study.BMJ open · 2019Article
- Ambient Air Pollution and Hospital Admissions for Peptic Ulcers in Taipei: A Time-Stratified Case-Crossover Study.International journal of environmental research and public health · 2019Article
- Review
- Inhalational exposure to particulate matter air pollution alters the composition of the gut microbiome.Environmental pollution (Barking, Essex : 1987) · 2018Article
- Air pollution and chronic airway diseases: what should people know and do?Journal of thoracic disease · 2016Review
- Article
- Role of environmental pollution in irritable bowel syndrome.World journal of gastroenterology · 2015Review
- Upper gastrointestinal bleeding due to peptic ulcer disease is not associated with air pollution: a case-crossover study.BMC gastroenterology · 2015Article
- Effect of exposure to atmospheric ultrafine particles on production of free fatty acids and lipid metabolites in the mouse small intestine.Environmental health perspectives · 2015Article
- Article
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11 authors.
Funding
Abstract
backgroundEnvironmental determinants of appendicitis are poorly understood. Past work suggests that air pollution may increase the risk of appendicitis.
objectivesWe investigated whether ambient ground-level ozone (O3) concentrations were associated with appendicitis and whether these associations varied between perforated and nonperforated appendicitis.
methodsWe based this time-stratified case-crossover study on 35,811 patients hospitalized with appendicitis from 2004 to 2008 in 12 Canadian cities. Data from a national network of fixed-site monitors were used to calculate daily maximum O3 concentrations for each city. Conditional logistic regression was used to estimate city-specific odds ratios (ORs) relative to an interquartile range (IQR) increase in O3 adjusted for temperature and relative humidity. A random-effects meta-analysis was used to derive a pooled risk estimate. Stratified analyses were used to estimate associations separately for perforated and nonperforated appendicitis.
resultsOverall, a 16-ppb increase in the 7-day cumulative average daily maximum O3 concentration was associated with all appendicitis cases across the 12 cities (pooled OR = 1.07; 95% CI: 1.02, 1.13). The association was stronger among patients presenting with perforated appendicitis for the 7-day average (pooled OR = 1.22; 95% CI: 1.09, 1.36) when compared with the corresponding estimate for nonperforated appendicitis [7-day average (pooled OR = 1.02, 95% CI: 0.95, 1.09)]. Heterogeneity was not statistically significant across cities for either perforated or nonperforated appendicitis (p > 0.20).
conclusionsHigher levels of ambient O3 exposure may increase the risk of perforated appendicitis.
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