ArticleBMC psychiatry2013
Altered cardiac autonomic nervous function in depression.
Article in BMC psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 4 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- Cardiovascular diseases and depression: A meta-analysis and Mendelian randomization analysis.Molecular psychiatry · 2025Pooled it
- Depression and Risk of Sudden Cardiac Death and Arrhythmias: A Systematic Review and Meta-Analysis.Reviews in cardiovascular medicine · 2025Pooled it
- Heart rate variability status at rest in adult depressed patients: a systematic review and meta-analysis.Frontiers in public health · 2023Pooled it
- Autonomic nervous system dysfunction in psychiatric disorders and the impact of psychotropic medications: a systematic review and meta-analysis.Journal of psychiatry & neuroscience : JPN · 2016Pooled it
- Neurocardiology: Brain-Heart Interactions in the Heart.MedComm · 2026Review
- Association between depressive symptoms and cognitive impairment among older adults in China: a mediation analysis of proactive health.BMC geriatrics · 2025Article
- Investigating the Role of Autonomic Dysfunction in the Pathogenesis of Depression-Related Dry Eye.Translational vision science & technology · 2025Article
- Electrocardiography-derived autonomic profiles in depression and suicide risk with insights from the UK Biobank.Npj mental health research · 2025Article
- Heart Rate Variability: Marker of the Impact of Cardiovascular Disease on Intrinsic Capacity in Older Adults.Journal of clinical medicine · 2025Article
- Role of sirtuin 1 in depression‑induced coronary heart disease: Molecular pathways and therapeutic potential (Review).Biomedical reports · 2025Review
- Changes in heart rate variability and hemodynamics of adolescents within the frontal cortex in response to face emotional stimulation.PloS one · 2025Article
- The effects of different types of dance interventions on the autonomic nervous system of college students with depressed mood.Frontiers in psychology · 2025Article
- A sex-specific pathway linking early life maltreatment, vagal activity, and depressive symptoms.European journal of psychotraumatology · 2024Article
- Central Autonomic Network and Heart Rate Variability in Premature Neonates.Developmental neuroscience · 2024Article
- Exploring a multimodal approach for utilizing digital biomarkers for childhood mental health screening.Frontiers in psychiatry · 2024Article
- Association of heart rate variability and C-reactive protein in patients with depression.Journal of family medicine and primary care · 2024Article
- [Latest Findings on the Interaction Mechanism Between Depressive Disorder and Intestinal Permeability].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023Review
- Cardiovascular disease and depression: a narrative review.Frontiers in cardiovascular medicine · 2023Review
- Are anxiety and depression associated with cognition and cardiovascular function in young male and female adults?PloS one · 2023Article
- Relationships of Physical Activity, Depression, and Sleep with Cognitive Function in Community-Dwelling Older Adults.International journal of environmental research and public health · 2022Observational
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDepression is an independent risk factor for coronary artery disease. Autonomic instability may play a mediating or moderating role in this relationship; however this is not well understood. The objective of this study was to explore cardiac autonomic function and cardiac arrhythmia in depression, the correlation between depression severity and Heart Rate Variability (HRV) related indices, and the prevalence of arrhythmia.
methodsIndividuals (n = 53) with major depression as assessed by the Diagnostic and Statistical Manual of Mental Disorders, who had a Hamilton Rating Scale for Depression (HAMD) score ≥20 and a Zung Self-Rating Depression Scale score > 53 were compared to 53 healthy individuals, matched for age and gender. Multichannel Electrocardiograph ECG-92C data were collected over 24 hours. Long-term changes in HRV were used to assess the following vagally mediated changes in autonomic tone, expressed as time domain indices: Standard deviation of the NN intervals (SDNN), standard deviation of 5 min averaged NN intervals (SDANN), Root Mean Square of the Successive Differences (RMSSD) and percentage of NN intervals > 50 ms different from preceding interval (pNN50). Pearson's correlations were conducted to explore the strength of the association between depression severity (using the SDS and HRV related indices, specifically SDNN and low frequency domain / high frequency domain (LF/HF)).
resultsThe values of SDNN, SDANN, RMSSD, PNN50 and HF were lower in the depression group compared to the control group (P<.05). The mean value of the LF in the depression group was higher than the in control group (P<.05). Furthermore the ratio of LF/HF was higher among the depression group than the control group (P<.05). A linear relationship was shown to exist between the severity of the depression and HRV indices. In the depression group, the prevalence of arrhythmia was significantly higher than in the control group (P<.05), particularly supraventricular arrhythmias.
conclusionsOur findings suggest that depression is accompanied by dysfunction of the cardiac autonomic nervous system, and further, that depression severity is linked to severity of this dysfunction. Individuals with depression appear to be susceptible to premature atrial and/or ventricular disease.
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Registered trials
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