ArticleBiomedical engineering online2013
Closed-loop real-time simulation model of hemodynamics and oxygen transport in the cardiovascular system.
Article in Biomedical engineering online, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Effect of the Mitral Valve on the Intra Ventricular Hemodynamics.International journal for numerical methods in biomedical engineering · 2026Article
- The haemodynamic envelope, a novel aviation-inspired safety framework for personalized monitoring in cardiogenic shock.European heart journal. Acute cardiovascular care · 2026Article
- Patient-Specific Size and Age Scaling in a Zero Dimensional Cardiovascular Model.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026Article
- Physiological Control of Realheart Total Artificial Heart.Artificial organs · 2025Article
- Experiments and Simulations to Assess Exercise-Induced Pressure Drop Across Aortic Coarctations.Journal of biomechanical engineering · 2025Article
- Observer- and sequence variability in personalized 4D flow MRI-based cardiovascular models.Scientific reports · 2025Article
- Walking-induced inertial effects on the cardiovascular system.Frontiers in network physiology · 2025Article
- The assessment of left ventricular diastolic function: guidance and recommendations from the British Society of Echocardiography.Echo research and practice · 2024Review
- Non-invasive pressure-volume loops using the elastance model and CMR: a porcine validation at transient pre-loads.European heart journal. Imaging methods and practice · 2024Article
- Turbulent blood dynamics in the left heart in the presence of mitral regurgitation: a computational study based on multi-series cine-MRI.Biomechanics and modeling in mechanobiology · 2023Article
- Arterial pulse wave modeling and analysis for vascular-age studies: a review from VascAgeNet.American journal of physiology. Heart and circulatory physiology · 2023Review
- Blood flow but not cannula positioning influences the efficacy of Veno-Venous ECMO therapy.Scientific reports · 2022Article
- An Investigation of Left Ventricular Valve Disorders and the Mechano-Electric Feedback Using a Synergistic Lumped Parameter Cardiovascular Numerical Model.Bioengineering (Basel, Switzerland) · 2022Article
- Impact of extra-anatomical bypass on coarctation fluid dynamics using patient-specific lumped parameter and Lattice Boltzmann modeling.Scientific reports · 2022Article
- Simultaneous visualization of flow fields and oxygen concentrations to unravel transport and metabolic processes in biological systems.Cell reports methods · 2022Article
- Distinct morphologies of arterial waveforms reveal preload-, contractility-, and afterload-deficient hemodynamic instability: An in silico simulation study.Physiological reports · 2022Article
- Cardiovascular Response to Posture Changes: Multiscale Modeling andFrontiers in physiology · 2022Article
- Ventricular wall stress and wall shear stress homeostasis predicts cardiac remodeling during pregnancy: A modeling study.International journal for numerical methods in biomedical engineering · 2022Article
- Initial clinical validation of a hybridFrontiers in physiology · 2022Article
- Personalized intervention cardiology with transcatheter aortic valve replacement made possible with a non-invasive monitoring and diagnostic framework.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundComputer technology enables realistic simulation of cardiovascular physiology. The increasing number of clinical surgical and medical treatment options imposes a need for better understanding of patient-specific pathology and outcome prediction.
methodsA distributed lumped parameter real-time closed-loop model with 26 vascular segments, cardiac modelling with time-varying elastance functions and gradually opening and closing valves, the pericardium, intrathoracic pressure, the atrial and ventricular septum, various pathological states and including oxygen transport has been developed.
resultsModel output is pressure, volume, flow and oxygen saturation from every cardiac and vascular compartment. The model produces relevant clinical output and validation of quantitative data in normal physiology and qualitative directions in simulation of pathological states show good agreement with published data.
conclusionThe results show that it is possible to build a clinically relevant real-time computer simulation model of the normal adult cardiovascular system. It is suggested that understanding qualitative interaction between physiological parameters in health and disease may be improved by using the model, although further model development and validation is needed for quantitative patient-specific outcome prediction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.