ArticleThe journal of physical chemistry. B2013
Structure and dynamics of urea/water mixtures investigated by vibrational spectroscopy and molecular dynamics simulation.
Article in The journal of physical chemistry. B, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- NMR insights into the role of urea in cellulose dissolution: A stoichiometric study of cellobiose in NaOH/urea aqueous solution.Magnetic resonance letters · 2026Article
- Excess Properties of Aqueous Dilutions of Ammonium- and Phosphonium-Based Deep Eutectic Solvents.Journal of chemical and engineering data · 2026Article
- Mechanism of Osmolyte Stabilization-Destabilization of Proteins: Experimental Evidence.The journal of physical chemistry. B · 2022Article
- Water-Induced Restructuring of the Surface of a Deep Eutectic Solvent.The journal of physical chemistry letters · 2022Article
- Direct Observation of the Orientation of Urea Molecules at Charged Interfaces.The journal of physical chemistry letters · 2021Article
- Photophysical Properties of BADAN Revealed in the Study of GGBP Structural Transitions.International journal of molecular sciences · 2021Article
- Remdesivir Strongly Binds to RNA-Dependent RNA Polymerase, Membrane Protein, and Main Protease of SARS-CoV-2: Indication From Molecular Modeling and Simulations.Frontiers in pharmacology · 2021Article
- Contrasting Effects of Guanidinium Chloride and Urea on the Activity and Unfolding of Lysozyme.ACS omega · 2018Article
- Time-dependent X-ray diffraction studies on urea/hen egg white lysozyme complexes reveal structural changes that indicate onset of denaturation.Scientific reports · 2016Article
- Proteins in binary solvents.Biophysical reviews · 2016Review
- Effects of the Hydration State on the Mid-Infrared Spectra of Urea and Creatinine in Relation to Urine Analyses.Applied spectroscopy · 2016Article
- Mechanism of Protein Denaturation: Partial Unfolding of the P22 Coat Protein I-Domain by Urea Binding.Biophysical journal · 2015Article
- Dispersion interactions between urea and nucleobases contribute to the destabilization of RNA by urea in aqueous solution.The journal of physical chemistry. B · 2015Article
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5 authors.
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Abstract
Urea/water is an archetypical "biological" mixture and is especially well-known for its relevance to protein thermodynamics as urea acts as a protein denaturant at high concentration. This behavior has given rise to an extended debate concerning urea's influence on water structure. On the basis of a variety of methods and of definitions of the water structure, urea has been variously described as a structure-breaker, a structure-maker, or as remarkably neutral toward water. Because of its sensitivity to microscopic structure and dynamics, vibrational spectroscopy can help resolve these debates. We report experimental and theoretical spectroscopic results for the OD stretch of HOD/H2O/urea mixtures (linear IR, 2DIR, and pump-probe anisotropy decay) and for the CO stretch of urea-D4/D2O mixtures (linear IR only). Theoretical results are obtained using existing approaches for water and a modification of a frequency map developed for acetamide. All absorption spectra are remarkably insensitive to urea concentration, consistent with the idea that urea only very weakly perturbs the water structure. Both this work and experiments by Rezus and Bakker, however, show that water's rotational dynamics are slowed down by urea. Analysis of the simulations casts doubt on the suggestion that urea immobilizes particular doubly hydrogen bonded water molecules.
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