Evidence map›Paper›PMID 23841064›Full record

ArticleBioMed research international2013

Reduced cortisol in boys with early-onset conduct disorder and callous-unemotional traits.

Georg G von Polier, Beate Herpertz-Dahlmann, Kerstin Konrad, Kristine Wiesler, Jana Rieke, Monika Heinzel-Gutenbrunner, Christian J Bachmann, Timo D Vloet

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Measuring Cortisol in the Classroom with School-Aged Children-A Systematic Review and Recommendations.International journal of environmental research and public health · 2018
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  15. Cortisol Response to Stress in Adults with Attention Deficit Hyperactivity Disorder.The international journal of neuropsychopharmacology · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Georg G von PolierDepartment of Child and Adolescent Psychiatry, Medical Faculty, RWTH Aachen University, Neuenhofer Weg 21, 52074 Aachen, Germany.
Beate Herpertz-Dahlmann
Kerstin Konrad
Kristine Wiesler
Jana Rieke
Monika Heinzel-Gutenbrunner
Christian J Bachmann
Timo D Vloet
RWTH Aachen University · DECharité - Universitätsmedizin Berlin · DEJülich Aachen Research Alliance · DEUniversitätsklinikum Gießen und Marburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA growing body of evidence suggests an association between altered hypothalamic-pituitary-adrenal axis reactivity and the development of persistent antisocial behavior in children. However the effects of altered cortisol levels remain poorly understood in the complex context of conduct disorder, callous-unemotional (CU) personality traits, and frequent comorbidities, such as attention deficit hyperactivity disorder (ADHD). The aim of the current study was to investigate associations among CU traits, antisocial behavior, and comorbid ADHD symptomatology with cortisol levels in male children and adolescents.

methodsThe study included 37 boys with early-onset conduct disorder (EO-CD, mean age 11.9 years) and 38 healthy boys (mean age 12.5 years). Participants were subjected to multiple daytime salivary cortisol measurements and a psychometric characterization.

resultsSubjects in the EO-CD group with elevated CU traits showed a diminished cortisol awakening response compared to healthy participants. In the EO-CD group, high CU traits and impulsivity were associated with decreased diurnal cortisol levels, while associations with antisocial behavior were not detected. The cortisol awakening response was significantly inversely associated with hyperactivity (P = 0.02) and marginally significant with CU traits (P = 0.07).

conclusionsThese results indicate a specific association between CU traits and a diminished stress response, which is not explained by antisocial behavior in general.

Indexed as

AdolescentAntisocial Personality DisorderAttention Deficit Disorder with HyperactivityChildConduct DisorderEmpathyHumansHydrocortisoneMaleHydrocortisone

Identifiers

PMID23841064
PMCPMC3693123
OpenAlexW2096033869

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.