ArticleBioMed research international2013
Comparison of ⁹⁹mTc-N-DBODC5 and ⁹⁹mTc-MIBI of myocardial perfusion imaging for diagnosis of coronary artery disease.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 15 citations in OpenAlex.
- Advancing Internal Dosimetry in Personalized Nuclear Medicine: Toward Optimized Radiopharmaceutical Use in Clinical Practice.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Myocardial Viability Testing in the Management of Ischemic Heart Failure.Life (Basel, Switzerland) · 2022Review
- Right ventricle performances with echocardiography andExperimental biology and medicine (Maywood, N.J.) · 2018Article
- Mitochondrial-Targeted Molecular Imaging in Cardiac Disease.BioMed research international · 2017Review
- New SPECT and PET radiopharmaceuticals for imaging cardiovascular disease.BioMed research international · 2014Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite recent advances in therapeutic and diagnostic approaches, coronary artery disease (CAD) and its related cardiac disorders represent the most common cause of death in the United States. Nuclear myocardial perfusion imaging (MPI) technologies play a pivotal role in the diagnosis and treatment design for CAD. Recently, in order to develop improved MPI agents for diagnosis of CAD, (99m)Tc-[bis(dimethoxypropylphosphinoethyl)-ethoxyethyl-amine(PNP5)]-[bis(N-ethoxyethyl)dithiocarbamato(DBODC)]nitride(N-DBODC5)((99m)Tc-N-DBODC5) with a faster liver clearance than conventional single-photon emission computed tomography (SPECT) imaging agents (technetium 99m sestamibi ((99m)Tc-MIBI) or technetium 99m tetrofosmin) has been introduced. In preclinical and phase I studies, (99m)Tc-N-DBODC5 has shown characteristics of an essentially ideal MPI tracer. Importantly, however, there is no data to support the use of (99m)Tc-N-DBODC5 to evaluate myocardial ischemia in patients with suspected CAD. The present study was designed to assess the clinical value of this agent; the findings of stress and rest MPI after the administration of this agent were compared to those of stress and rest (99m)Tc-MIBI, as well as those of coronary angiography, with respect to the detection of CAD. Our findings indicated the usefulness of (99m)Tc-N-DBODC5 as a promising MPI agent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.