ArticleNephro-urology monthly2013
Relationship between serum cystatin C and creatinine or dialysis adequacy in patients on chronic maintenance hemodialysis.
Article in Nephro-urology monthly, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Pretransplant Serum Creatinine in Peritoneal Dialysis Patients Predicts Graft Outcomes.Kidney medicine · 2025Article
- Levels of cystatin C in low- and high-flux hemodialysis in children with end-stage renal disease.Pediatric nephrology (Berlin, Germany) · 2017Observational
- Serum cystatin C as a marker of renal function in critically ill patients with normal serum creatinine.Nephro-urology monthly · 2014Article
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5 authors.
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Abstract
backgroundGlomerular filtration rate (GFR) is widely estimated by serum creatinine based equations such as Cockcroft-Gault (CG) standardized for body surface, and an abbreviated formula derived from MDRD (modification of diet in renal disease) study. However, some studies suggested that creatinine based estimation of GFR formula can be replaced by cystatin C based formula.
objectivesThe aim of this study was to determine whether cystatin C based equation could be used as an indicator for renal function in hemodialysis patients compared to MDRD equation; and whether cystatin C, a dialyzable molecule, was related to Kt/V, the marker for dialysis adequacy. PATIENTS AND
methodsIn this cross-sectional study, 98 patients on chronic hemodialysis were included. Plasma levels of urea and creatinine were measured before and after dialysis, and cystatin C was measured before dialysis. GFR was calculated and compared.
resultsThe mean age of patients was 55.50 ± 16.10 (24-86) years and 66 cases were male (67.3%). The GFR was estimated at 6.05 ± 2.36 and 5.83 ± 2.19 cc/min by MDRD and cystatin C based formulas, respectively, with a significant correlation (r = 0.51; P < 0.001). Serum cystatin C level was 9.74 ± 2.47 mg/L which showed significant reverse correlation with both MDRD (r = -0.46; P < 0.001) and cystatin C based formulas (r = -0.87; P < 0.001). Neither creatinine nor serum cystatin C showed correlation with Kt/V, as the marker of dialysis adequacy.
conclusionsSerum cystatin C may be considered as an indicator of renal function in patients under maintenance hemodialysis.
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