ArticleeLife2013
Fungal effector Ecp6 outcompetes host immune receptor for chitin binding through intrachain LysM dimerization.
Article in eLife, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 1 of them a synthesis that pooled it.
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Who cites it
109 citing papers in PubMed, 1 synthesis or guideline pooled it, 263 citations in OpenAlex.
- Tandem-repeat lectins: structural and functional insights.Glycobiology · 2024Pooled it
- Lysin Motif Effectors Facilitate the Endophytic Colonization of Wheat by Sclerotinia sclerotiorum via Modulating Plant Immunity.Molecular plant pathology · 2026Article
- The glycosylated root-knot nematode effector Minc10750 suppresses plant immunity by destabilizing host chitinases.The New phytologist · 2026Article
- A structurally unique effector shared between vascular wilt fungi drives cotton and olive defoliation.Nature communications · 2026Article
- Advanced Research on LysM Domain-Containing Proteins: Functional Mechanisms and Roles in Pathogenicity of Plant Fungi.International journal of molecular sciences · 2026Review
- AtLYK4 is the major chitin receptor in Arabidopsis with N-glycosylation and ligand-interacting residues orchestrating chitin perception.Science China. Life sciences · 2026Article
- Plant cell walls as a key driver of plant-pathogen coevolution.FEMS microbiology reviews · 2026Review
- Undermining the cry for help: the phytopathogenic fungus Verticillium dahliae secretes an antimicrobial effector protein to undermine host recruitment of antagonistic Pseudomonas bacteria.The New phytologist · 2026Article
- Emerging roles of protein modifications in sexual reproduction and pathogenesis of filamentous fungi.Frontiers in microbiology · 2026Review
- Grapevine protein Src2 mediates plant disease resistance during Lasiodiplodia theobromae infection.Plant physiology · 2025Article
- Secreted LysM proteins are required for niche competition and full virulence in Pseudomonas savastanoi during host plant infection.PLoS pathogens · 2025Article
- Structure-guided insights into the biology of fungal effectors.The New phytologist · 2025Review
- Predicting receptor-ligand pairing preferences in plant-microbe interfaces via molecular dynamics and machine learning.Computational and structural biotechnology journal · 2025Article
- Identification and NMR-based structural characterization of the functional domain of EPC3, a virulence effector of the phytopathogenic fungusFrontiers in plant science · 2025Article
- A Virulence Factor fromPlants (Basel, Switzerland) · 2024Article
- Rice false smut virulence protein subverts host chitin perception and signaling at lemma and palea for floral infection.The Plant cell · 2024Article
- Interactive transcriptome analyses of Northern Wild Rice (Frontiers in plant science · 2024Article
- Deacetylation of chitin oligomers by Fusarium graminearum polysaccharide deacetylase suppresses plant immunity.Molecular plant pathology · 2023Article
- Plant lysin motif extracellular proteins are required for arbuscular mycorrhizal symbiosis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Silencing a Chitinase Gene,International journal of molecular sciences · 2023Article
49 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While host immune receptors detect pathogen-associated molecular patterns to activate immunity, pathogens attempt to deregulate host immunity through secreted effectors. Fungi employ LysM effectors to prevent recognition of cell wall-derived chitin by host immune receptors, although the mechanism to compete for chitin binding remained unclear. Structural analysis of the LysM effector Ecp6 of the fungal tomato pathogen Cladosporium fulvum reveals a novel mechanism for chitin binding, mediated by intrachain LysM dimerization, leading to a chitin-binding groove that is deeply buried in the effector protein. This composite binding site involves two of the three LysMs of Ecp6 and mediates chitin binding with ultra-high (pM) affinity. Intriguingly, the remaining singular LysM domain of Ecp6 binds chitin with low micromolar affinity but can nevertheless still perturb chitin-triggered immunity. Conceivably, the perturbation by this LysM domain is not established through chitin sequestration but possibly through interference with the host immune receptor complex. DOI:http://dx.doi.org/10.7554/eLife.00790.001.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.