ArticleeLife2013
A longitudinal study of Caenorhabditis elegans larvae reveals a novel locomotion switch, regulated by G(αs) signaling.
Article in eLife, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 27 citations in OpenAlex.
- Automated analysis of C. elegans behavior by LabGym: an open-source, AI-powered platform.G3 (Bethesda, Md.) · 2026Article
- Functional Insights into Protein Kinase A (PKA) Signaling fromLife (Basel, Switzerland) · 2022Review
- Behavioral States.Genetics · 2020Review
- A wake-active locomotion circuit depolarizes a sleep-active neuron to switch on sleep.PLoS biology · 2020Article
- Powerful and interpretable behavioural features for quantitative phenotyping ofPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Food responsiveness regulates episodic behavioral states inJournal of neurophysiology · 2017Article
- Inactivity periods and postural change speed can explain atypical postural change patterns of Caenorhabditis elegans mutants.BMC bioinformatics · 2017Article
- The Neuropeptides FLP-2 and PDF-1 Act in Concert To Arouse Caenorhabditis elegans Locomotion.Genetics · 2016Article
- HandKAchip - Hands-free killing assay on a chip.Scientific reports · 2016Article
- Review
- Serotonin promotes exploitation in complex environments by accelerating decision-making.BMC biology · 2016Article
- Caenorhabditis elegans exhibit a coupling between the defecation motor program and directed locomotion.Scientific reports · 2015Article
- Distinct Mechanisms Underlie Quiescence during Two Caenorhabditis elegans Sleep-Like States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- A Generative Statistical Algorithm for Automatic Detection of Complex Postures.PLoS computational biology · 2015Article
- Sensory Neurons Arouse C. elegans Locomotion via Both Glutamate and Neuropeptide Release.PLoS genetics · 2015Article
- Agarose Microchambers for Long-term Calcium Imaging of Caenorhabditis elegans.Journal of visualized experiments : JoVE · 2015Article
- Homeostasis in C. elegans sleep is characterized by two behaviorally and genetically distinct mechanisms.eLife · 2014Article
- Article
- Measurements of behavioral quiescence in Caenorhabditis elegans.Methods (San Diego, Calif.) · 2014Article
- Neurobiology ofBioscience · 2014Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Despite their simplicity, longitudinal studies of invertebrate models are rare. We thus sought to characterize behavioral trends of Caenorhabditis elegans, from the mid fourth larval stage through the mid young adult stage. We found that, outside of lethargus, animals exhibited abrupt switching between two distinct behavioral states: active wakefulness and quiet wakefulness. The durations of epochs of active wakefulness exhibited non-Poisson statistics. Increased Gαs signaling stabilized the active wakefulness state before, during and after lethargus. In contrast, decreased Gαs signaling, decreased neuropeptide release, or decreased CREB activity destabilized active wakefulness outside of, but not during, lethargus. Taken together, our findings support a model in which protein kinase A (PKA) stabilizes active wakefulness, at least in part through two of its downstream targets: neuropeptide release and CREB. However, during lethargus, when active wakefulness is strongly suppressed, the native role of PKA signaling in modulating locomotion and quiescence may be minor. DOI:http://dx.doi.org/10.7554/eLife.00782.001.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.