ArticlePloS one2013
Study in vivo intraocular biocompatibility of in situ gelation hydrogels: poly(2-ethyl oxazoline)-block-poly(ε-caprolactone)-block-poly(2-ethyl oxazoline) copolymer, matrigel and pluronic F127.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Evaluation of Propolis and Diclofenac Sodium Eye Drops for Animals: Physicochemical Properties and In Vitro Biological Activity.Gels (Basel, Switzerland) · 2026Article
- Thermosensitive In Situ Ophthalmic Gel for Effective Local Delivery and Antifungal Activity of Ketoconazole Nanoparticles.Gels (Basel, Switzerland) · 2024Article
- In vivo evaluation of a Nano-enabled therapeutic vitreous substitute for the precise delivery of triamcinolone to the posterior segment of the eye.Drug delivery and translational research · 2024Article
- Advances in Polysaccharide- and Synthetic Polymer-Based Vitreous Substitutes.Pharmaceutics · 2023Review
- Polyaphron Formulations Stabilised with Different Water-Soluble Polymers for Ocular Drug Delivery.Pharmaceutics · 2022Article
- Synthesis and Investigation of Thermo-Induced Gelation of Partially Cross-Linked Poly-2-isopropyl-2-oxazoline in Aqueous Media.Polymers · 2020Article
- Long-term therapeutic effect in nonhuman primate eye from a single injection of anti-VEGF controlled release hydrogel.Bioengineering & translational medicine · 2019Article
- Morphological study of dynamic culture of thermosensitive collagen hydrogel in constructing tissue engineering complex.Bioengineered · 2016Article
- Injectable Chemically Crosslinked Hydrogel for the Controlled Release of Bevacizumab in Vitreous: A 6-Month In Vivo Study.Translational vision science & technology · 2015Article
- Dynamic culture of a thermosensitive collagen hydrogel as an extracellular matrix improves the construction of tissue-engineered peripheral nerve.Neural regeneration research · 2014Article
- Biocompatible reverse thermal gel sustains the release of intravitreal bevacizumab in vivo.Investigative ophthalmology & visual science · 2014Article
- Vitreous substitutes: the present and the future.BioMed research international · 2014Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The long term in vivo biocompatibility is an essential feature for the design and development of sustained drug release carriers. In the recent intraocular drug delivery studies, hydrogels were suggested as sustained release carriers. The biocompatibility test for these hydrogels, however, was commonly performed only through in vitro cell culture examination, which is insufficient before the clinical applications. We compared three thermosensitive hydrogels that have been suggested as the carriers for drugs by their gel-solution phase-change properties. A new block terpolymer (PEOz-PCL-PEOz, ECE) and two commercial products (Matrigel® and Pluronic F127) were studied. The results demonstrated that the ocular media remained translucent for ECE and Pluronic F127 in the first 2 weeks, but cataract formation for Matrigel occurred in 2 weeks and for Pluronic F127 in 1 month, while turbid media was observed for both Matrigel and Pluronic F127 in 2 months. The electrophysiology examinations showed significant neuroretinal toxicity of Matrigel and Pluronic F127 but good biocompatibility of ECE. The neuroretinal toxicity of Matrigel and Pluronic F127 and superior biocompatibility of ECE hydrogel suggests ECE as more appropriate biomaterial for use in research and potentially in intraocular application.
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