ArticlePloS one2013
Permanent and transient congenital hypothyroidism in Fayoum, Egypt: a descriptive retrospective study.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Permanent or Transient Congenital Hypothyroidism: A Diagnostic Dilemma.Acta paediatrica (Oslo, Norway : 1992) · 2026Review
- Predictive factors of permanent versus transient congenital hypothyroidism: a pragmatic cohort study.Annals of pediatric endocrinology & metabolism · 2025Article
- Predictive Factors of Transient Congenital Hypothyroidism among Filipino Children: A Retrospective Study.Acta medica Philippina · 2025Article
- The natural course of newborns with transient congenital hypothyroidism.Endocrine connections · 2024Article
- Diagnostic options, physiopathology, risk factors and genetic causes of permanent congenital hypothyroidism: A narrative review.Caspian journal of internal medicine · 2024Review
- Congenital hypothyroidism in India: A systematic review and meta-analysis of prevalence, screen positivity rates, and etiology.The Lancet regional health. Southeast Asia · 2022Article
- Prevalence of transient congenital hypothyroidism among neonates.Annals of medicine and surgery (2012) · 2021Article
- Prevalence and predictive factors of transient and permanent congenital hypothyroidism in Fars province, Iran.BMC pediatrics · 2021Article
- Validity of Six Month L-Thyroxine Dose for Differentiation of Transient or Permanent Congenital HypothyroidismJournal of clinical research in pediatric endocrinology · 2020Article
- Congenital hypothyroidism: a five-year retrospective study at Children's University Hospital, Damascus, Syria.Qatar medical journal · 2019Article
- Congenital hypothyroidism in different cities of the Isfahan province: A descriptive retrospective study.Journal of education and health promotion · 2019Article
- A 7-year study on the prevalence of congenital hypothyroidism in northern Iran.Electronic physician · 2018Article
- Transient hypothyroidism in the newborn: to treat or not to treat.Translational pediatrics · 2017Review
- Thyroid status of iodine deficient newborn infants living in central region of Turkey: a pilot study.World journal of pediatrics : WJP · 2017Article
- Permanent and Transient Congenital Hypothyroidism in Hamadan West Province of Iran.International journal of endocrinology and metabolism · 2016Article
- Incidence and Interrelated Factors in Patients With Congenital Hypothyroidism as Detected by Newborn Screening in Guangxi, China.Global pediatric health · 2015Article
- Agenesis and not ectopia is common in North Indian children with thyroid dysgenesis.Indian journal of endocrinology and metabolism · 2014Article
- Congenital hypothyroidism and the importance of universal newborn screening.Indian journal of pediatrics · 2014Review
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2 authors.
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Abstract
backgroundCongenital hypothyroidism (CH) is one of the most common preventable causes of mental retardation. One important challenge in understanding the epidemiology of CH is that some newborns will have transient CH, a temporary depression of thyroid hormone concentrations that can last from several days to several months. Studies from other countries have reported that 10 to 15% of children treated for CH ultimately prove not to need treatment past 3 years of age to maintain normal hormone concentrations, and thus have transient hypothyroidism. The purpose of this study was to determine the prevalence of permanent and transient congenital hypothyroidism in Fayoum, Egypt.
methodsCases detected by Fayoum neonatal screening program (NSP) between January 2003 and December 2011, and followed up at health insurance center were included. Permanent or transient CH was determined using results of thyroid function tests.
resultsOf the 248 patients diagnosed primarily with CH by NSP; 204 (82.3%) patients were diagnosed to have permanent CH (prevalence 1/3587 live birth), and 44 (17.7%) patients were diagnosed to have transient CH (prevalence 1/16667 live birth). Initial TSH levels were higher in permanent CH cases than transient cases (p<0.004). Female to male ratio was 0.8 and 0.7 in permanent and transient CH respectively. 161 (65%) patients had thyroid dysgenesis (107 ectopic thyroid gland, 28 athyreosis and 26 thyroid hypoplasia). 87 (35%) patients had intact gland in thyroid scan and were considered to have dyshormonogenesis. Of these 87 patients 44 proved to have transient CH and 43 had permanent CH.
conclusionThe preliminary data from our study revealed that the incidences of CH as well as the permanent form were similar to worldwide reports. Although the high incidence of transient CH in our study could be explained by iodine deficiency further studies are needed to confirm the etiology and plan the treatment strategies.
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