ArticlePloS one2013
Epileptic discharges affect the default mode network--FMRI and intracerebral EEG evidence.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Social cognition in children and adolescents with epilepsy: A meta-analysis.Frontiers in psychiatry · 2022Pooled it
- The dynamic functional connectivity peak index: Detection of interictal epileptic activity with fMRI.Epilepsia · 2026Article
- Mapping the Phenotypic Spectrum of Occipital Lobe Epilepsy: A SEEG-Defined Network Classification.CNS neuroscience & therapeutics · 2026Article
- Novel noninvasive identification of patient-specific epileptic networks in focal epilepsies: Linking single-photon emission computed tomography perfusion during seizures with resting-state magnetoencephalography dynamics.Human brain mapping · 2023Article
- Consciousness, 4E cognition and Aristotle: a few conceptual and historical aspects.Frontiers in computational neuroscience · 2023Review
- Alternations of neuromagnetic activity across neurocognitive core networks among benign childhood epilepsy with centrotemporal spikes: A multi-frequency MEG study.Frontiers in neuroscience · 2023Article
- Clinical Usefulness of Simultaneous Electroencephalography and Functional Magnetic Resonance Imaging in Children With Focal Epilepsy.Journal of clinical neurology (Seoul, Korea) · 2022Article
- Relationship between brain activity, cognitive function, and sleep spiking activation in new-onset self-limited epilepsy with centrotemporal spikes.Frontiers in neurology · 2022Article
- Phase Resetting in the Anterior Cingulate Cortex Subserves Childhood Attention and Is Impaired by Epilepsy.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- How cerebral cortex protects itself from interictal spikes: The alpha/beta inhibition mechanism.Human brain mapping · 2021Article
- [Epilepsy in the aged : Challenges in diagnostics and treatment].Zeitschrift fur Gerontologie und Geriatrie · 2021Article
- An ESR Framework for the Study of Consciousness.Entropy (Basel, Switzerland) · 2021Article
- Mapping Epileptic Networks Using Simultaneous Intracranial EEG-fMRI.Frontiers in neurology · 2021Article
- Identification of Negative BOLD Responses in Epilepsy Using Windkessel Models.Frontiers in neurology · 2021Article
- A Comprehensive Review of Brain Connectomics and Imaging to Improve Deep Brain Stimulation Outcomes.Movement disorders : official journal of the Movement Disorder Society · 2020Review
- Inhibiting Epileptiform Activity in Cognitive Disorders: Possibilities for a Novel Therapeutic Approach.Frontiers in neuroscience · 2020Review
- Frequency-Dependent Interictal Neuromagnetic Activities in Children With Benign Epilepsy With Centrotemporal Spikes: A Magnetoencephalography (MEG) Study.Frontiers in human neuroscience · 2020Article
- GABAergic Inhibitory Interneuron Deficits in Alzheimer's Disease: Implications for Treatment.Frontiers in neuroscience · 2020Review
- Lesion Network Localization of Seizure Freedom following MR-guided Laser Interstitial Thermal Ablation.Scientific reports · 2019Article
- Cognition and dementia in older patients with epilepsy.Brain : a journal of neurology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Functional neuroimaging studies of epilepsy patients often show, at the time of epileptic activity, deactivation in default mode network (DMN) regions, which is hypothesized to reflect altered consciousness. We aimed to study the metabolic and electrophysiological correlates of these changes in the DMN regions. We studied six epilepsy patients that underwent scalp EEG-fMRI and later stereotaxic intracerebral EEG (SEEG) sampling regions of DMN (posterior cingulate cortex, Pre-cuneus, inferior parietal lobule, medial prefrontal cortex and dorsolateral frontal cortex) as well as non-DMN regions. SEEG recordings were subject to frequency analyses comparing sections with interictal epileptic discharges (IED) to IED-free baselines in the IED-generating region, DMN and non-DMN regions. EEG-fMRI and SEEG were obtained at rest. During IEDs, EEG-fMRI demonstrated deactivation in various DMN nodes in 5 of 6 patients, most frequently the pre-cuneus and inferior parietal lobule, and less frequently the other DMN nodes. SEEG analyses demonstrated decrease in gamma power (50-150 Hz), and increase in the power of lower frequencies (<30 Hz) at times of IEDs, in at least one DMN node in all patients. These changes were not apparent in the non-DMN regions. We demonstrate that, at the time of IEDs, DMN regions decrease their metabolic demand and undergo an EEG change consisting of decreased gamma and increased lower frequencies. These findings, specific to DMN regions, confirm in a pathological condition a direct relationship between DMN BOLD activity and EEG activity. They indicate that epileptic activity affects the DMN, and therefore may momentarily reduce the consciousness level and cognitive reserve.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.