ArticlePloS one2013
Diffusion tensor magnetic resonance imaging of the brain in APP transgenic mice: a cohort study.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diffusion Tensor Imaging-Based Studies at the Group-Level Applied to Animal Models of Neurodegenerative Diseases.Frontiers in neuroscience · 2020Pooled it
- Age-dependent microstructure alterations in 5xFAD mice by high-resolution diffusion tensor imaging.Frontiers in neuroscience · 2022Article
- Magnetic Resonance Imaging in Animal Models of Alzheimer's Disease Amyloidosis.International journal of molecular sciences · 2021Review
- Article
- Structural brain signature of cognitive decline in Parkinson's disease: DTI-based evidence from the LANDSCAPE study.Therapeutic advances in neurological disorders · 2019Article
- Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in theTranslational neurodegeneration · 2019Article
- Ventral Striatal D2/3 Receptor Availability Is Associated with Impulsive Choice Behavior As Well As Limbic Corticostriatal Connectivity.The international journal of neuropsychopharmacology · 2018Article
- Diffusion tensor imaging using multiple coils for mouse brain connectomics.NMR in biomedicine · 2018Article
- Functional Connectivity Mapping in the Animal Model: Principles and Applications of Resting-State fMRI.Frontiers in neurology · 2017Review
- In Vivo Detection of Gray Matter Neuropathology in the 3xTg Mouse Model of Alzheimer's Disease with Diffusion Tensor Imaging.Journal of Alzheimer's disease : JAD · 2017Article
- The fornix provides multiple biomarkers to characterize circuit disruption in a mouse model of Alzheimer's disease.NeuroImage · 2016Article
- Altered whole-brain white matter networks in preclinical Alzheimer's disease.NeuroImage. Clinical · 2015Article
- Associations between white matter microstructure and amyloid burden in preclinical Alzheimer's disease: A multimodal imaging investigation.NeuroImage. Clinical · 2014Article
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6 authors.
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Abstract
introductionFast in-vivo high resolution diffusion tensor imaging (DTI) of the mouse brain has recently been shown to enable cohort studies by the combination of appropriate pulse sequences and cryogenically cooled resonators (CCR). The objective of this study was to apply this DTI approach at the group level to β-amyloid precursor protein (APP) transgenic mice.
methodsTwelve mice (5 wild type, 7 APP transgenic tg2576) underwent DTI examination at 156(2) × 250 µm(3) spatial resolution with a CCR at ultrahigh field (11.7 T). Diffusion images were acquired along 30 gradient directions plus 5 references without diffusion encoding with a total acquisition time of 35 minutes. Fractional anisotropy (FA) maps were statistically compared by whole brain-based spatial statistics (WBSS) at the group level vs. wild type controls.
resultsFA-map comparison showed characteristic regional patterns of differences between the groups with localizations associated with Alzheimer's disease in humans, such as the hippocampus, the entorhinal cortex, and the caudoputamen.
conclusionIn this proof-of-principle study, regions associated with amyloid-β deposition could be identified by WBSS of FA maps in APP transgenic mice vs. wild type mice. Thus, DTI in the mouse brain acquired at 11.7 T by use of a CCR was demonstrated to be feasible for cohort studies.
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