Evidence map›Paper›PMID 23840664›Full record

SynthesisPloS one2013

Job strain and cardiovascular disease risk factors: meta-analysis of individual-participant data from 47,000 men and women.

Solja T Nyberg, Eleonor I Fransson, Katriina Heikkilä, Lars Alfredsson, Annalisa Casini, Els Clays, Dirk De Bacquer, Nico Dragano, Raimund Erbel, Jane E Ferrie and 19 more

Abstract readMeta-Analysis
In one paragraph

Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Cardiovascular Health of Single Mothers: A Systematic Review.Journal of the American Heart Association · 2025
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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Solja T NybergFinnish Institute of Occupational Health, Helsinki and Tampere, Finland. solja.nyberg@ttl.fi
Eleonor I Fransson
Katriina Heikkilä
Lars Alfredsson
Annalisa Casini
Els Clays
Dirk De Bacquer
Nico Dragano
Raimund Erbel
Jane E Ferrie
Mark Hamer
Karl-Heinz Jöckel
France Kittel
Anders Knutsson
Karl-Heinz Ladwig
Thorsten Lunau
Michael G Marmot
Maria Nordin
Reiner Rugulies
Johannes Siegrist
Andrew Steptoe
Peter J M Westerholm
Hugo Westerlund
Töres Theorell
Eric J Brunner
Archana Singh-Manoux
G David Batty
Mika Kivimäki
IPD-Work Consortium

Funding

Socioeconomic gradient in CHD in early old ageR01HL036310 · NHLBI · UNIVERSITY OF LONDON · PI KIVIMAKI, MIKA J, MARMOT, MICHAEL G · 1986 to 2012
$3.1M
Health behaviors over the adult lifecourse and cognitive agingR01AG034454 · NIA · UNIVERSITY COLLEGE LONDON · PI KIVIMAKI, MIKA J, SINGH-MANOUX, ARCHANA · 2009 to 2013
$1.5M
British Heart Foundation RG/07/008/23674British Heart Foundation RG/13/2/30098Medical Research Council G0100222Medical Research Council G0601647Medical Research Council G0701830Medical Research Council G0902037Medical Research Council G1000616Medical Research Council G19/35Medical Research Council G8802774Medical Research Council K013351Medical Research Council MR/K026992/1NHLBI NIH HHS R01 HL036310NHLBI NIH HHS R01HL036310NIA NIH HHS R01 AG034454NIA NIH HHS R01AG034454Wellcome Trust
6 · The paper itself

Abstract

backgroundJob strain is associated with an increased coronary heart disease risk, but few large-scale studies have examined the relationship of this psychosocial characteristic with the biological risk factors that potentially mediate the job strain - heart disease association. METHODOLOGY AND PRINCIPAL

findingsWe pooled cross-sectional, individual-level data from eight studies comprising 47,045 participants to investigate the association between job strain and the following cardiovascular disease risk factors: diabetes, blood pressure, pulse pressure, lipid fractions, smoking, alcohol consumption, physical inactivity, obesity, and overall cardiovascular disease risk as indexed by the Framingham Risk Score. In age-, sex-, and socioeconomic status-adjusted analyses, compared to those without job strain, people with job strain were more likely to have diabetes (odds ratio 1.29; 95% CI: 1.11-1.51), to smoke (1.14; 1.08-1.20), to be physically inactive (1.34; 1.26-1.41), and to be obese (1.12; 1.04-1.20). The association between job strain and elevated Framingham risk score (1.13; 1.03-1.25) was attributable to the higher prevalence of diabetes, smoking and physical inactivity among those reporting job strain.

conclusionsIn this meta-analysis of work-related stress and cardiovascular disease risk factors, job strain was linked to adverse lifestyle and diabetes. No association was observed between job strain, clinic blood pressure or blood lipids.

Indexed as

Cardiovascular DiseasesCross-Sectional StudiesDiabetes Mellitus, Type 2FemaleHumansMaleOdds RatioRisk FactorsStress, PsychologicalWork

Identifiers

PMID23840664
PMCPMC3688665

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.