ArticlePloS one2013
Cognitive function in adult offspring of women with gestational diabetes--the role of glucose and other factors.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Maternal Diabetes and Cognitive Performance in the Offspring: A Systematic Review and Meta-Analysis.PloS one · 2015Pooled it
- Gestational diabetes mellitus and children's social-emotional development, behavioral problems, and psychological adjustment.Pediatric research · 2026Article
- Association between maternal glycohemoglobin in pregnancy and adult offspring cognition: results from the Transgenerational Effects of Adult Morbidity (TEAM) Study.Journal of developmental origins of health and disease · 2025Article
- Ophthalmic Changes in the Offspring of Pregnant Women with Gestational Diabetes Mellitus or Diabetes Mellitus - A Systematic Review.Clinical ophthalmology (Auckland, N.Z.) · 2025Review
- Clinical Characteristics of Offspring Born to Parents with Type 2 Diabetes Diagnosed in Youth: Observations from TODAY.Children (Basel, Switzerland) · 2024Article
- Regulatory Role of Insulin on Endogenous L1 ORF1 and NEFM Gene Expression through PI3K Signaling Pathway Specifically in Neuroblastoma Cell Line.Iranian journal of public health · 2023Article
- Language Impairment in Children of Mothers with Gestational Diabetes, Preeclampsia, and Preterm Delivery: Current Hypothesis and Potential Underlying Mechanisms : Language Impartment and Pregnancy Complications.Advances in experimental medicine and biology · 2023Article
- Cerebral Effects of Neonatal Dysglycemia.Clinics in perinatology · 2022Review
- Cognitive and Motor Development in 3- to 6-Year-Old Children Born to Mothers with Hyperglycaemia First Detected in Pregnancy in an Urban African Population.Maternal and child health journal · 2022Article
- The German Gestational Diabetes Study (PREG), a prospective multicentre cohort study: rationale, methodology and design.BMJ open · 2022Article
- No Clinically Relevant Memory Effects in Perinatal Hyperglycemia and Hypoglycemia: A 40-Year Follow-Up of a Small Cohort.Frontiers in public health · 2022Article
- Academic Performance in Adolescents Born to Mothers With Gestational Diabetes-A National Danish Cohort Study.The Journal of clinical endocrinology and metabolism · 2021Article
- Maternal glucose tolerance in pregnancy and child cognitive and behavioural problems in early and mid-childhood.Paediatric and perinatal epidemiology · 2021Article
- Neurodevelopmental outcomes after moderate to severe neonatal hypoglycemia.European journal of pediatrics · 2020Article
- Gestational diabetes and the human salivary microbiota: a longitudinal study during pregnancy and postpartum.BMC pregnancy and childbirth · 2020Observational
- Comparative Studies of the Gut Microbiota in the Offspring of Mothers With and Without Gestational Diabetes.Frontiers in cellular and infection microbiology · 2020Article
- Maternal glycemic control in diabetic pregnancies and neurodevelopmental outcomes in preschool aged children. A prospective cohort study.Early human development · 2019Article
- Oxidative Stress, Maternal Diabetes, and Autism Spectrum Disorders.Oxidative medicine and cellular longevity · 2018Review
- Maternal Diabetes and Fetal Programming Toward Neurological Diseases: Beyond Neural Tube Defects.Frontiers in endocrinology · 2018Review
- An Analysis into Metacognition and Family History of Diabetes Mellitus among First Year Medical Students.Journal of clinical and diagnostic research : JCDR · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe aimed to evaluate cognitive function in adult offspring of women with diet-treated gestational diabetes and to study potential associations with maternal glucose values. MATERIALS AND
methodsIn 2003-2005 cognitive function was assessed in a cohort of 18-27 year old offspring of women with diet-treated gestational diabetes mellitus (n = 153) and offspring from the background population (n = 118). The main outcome measure was global cognitive score derived from Raven's Progressive Matrices and three verbal subtests from the Weschler Adult Intelligence Scale. Maternal fasting- and 2-hour blood glucose values from the diagnostic oral glucose tolerance test were used as exposure variables.
resultsOffspring of women with gestational diabetes mellitus had a lower global cognitive score, than offspring from the background population (93.1 vs. 100.0, P<0.001). However, when adjusted for maternal age at delivery, parity, smoking during pregnancy, pre-pregnancy overweight, family social class, parental educational level, gender, birth weight, gestational age, perinatal complications and offspring age at follow-up, the difference was no longer statistically significant. Offspring global cognitive score decreased significantly with increasing maternal fasting glucose (β = -4.5, 95% CI -8.0 to -0.9, P = 0.01) and 2-hour glucose (β = -1.5, -2.9 to -0.2, P = 0.03) in univariate general linear models, but not when adjusted for family social class and parental educational level.
conclusionsLower cognitive test scores in adult offspring of women with diet-treated gestational diabetes were explained by well known predictors of cognitive function, but not by maternal hyperglycaemia during pregnancy. We find it reassuring that mild intrauterine hyperglycaemia does not seem to have adverse effect on offspring cognitive function.
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Registered trials
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