ArticlePloS one2013
The detection of novelty relies on dopaminergic signaling: evidence from apomorphine's impact on the novelty N2.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Catecholaminergic Regulation of Learning Rate in a Dynamic Environment.PLoS computational biology · 2016Trial
- Pupil Dilation and the Slow Wave ERP Reflect Surprise about Choice Outcome Resulting from Intrinsic Variability in Decision Confidence.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- How to optimize knowledge construction in the brain.NPJ science of learning · 2020Review
- Neural anomalies during vigilance in schizophrenia: Diagnostic specificity and genetic associations.NeuroImage. Clinical · 2020Article
- The value of novelty in schizophrenia.Schizophrenia research · 2018Article
- Picture Novelty Influences Response Selection and Inhibition: The Role of the In-Group Bias and Task-Difficulty.PloS one · 2016Article
- The Idea Is Good, but…: Failure to Replicate Associations of Oxytocinergic Polymorphisms with Face-Inversion in the N170.PloS one · 2016Article
- Article
- Decreased entropy modulation of EEG response to novelty and relevance in schizophrenia during a P300 task.European archives of psychiatry and clinical neuroscience · 2015Article
- Dopamine modulates novelty seeking behavior during decision making.Behavioral neuroscience · 2014Article
- Exploring a novel environment improves motivation and promotes recall of words.Frontiers in psychology · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite much research, it remains unclear if dopamine is directly involved in novelty detection or plays a role in orchestrating the subsequent cognitive response. This ambiguity stems in part from a reliance on experimental designs where novelty is manipulated and dopaminergic activity is subsequently observed. Here we adopt the alternative approach: we manipulate dopamine activity using apomorphine (D1/D2 agonist) and measure the change in neurological indices of novelty processing. In separate drug and placebo sessions, participants completed a von Restorff task. Apomorphine speeded and potentiated the novelty-elicited N2, an Event-Related Potential (ERP) component thought to index early aspects of novelty detection, and caused novel-font words to be better recalled. Apomorphine also decreased the amplitude of the novelty-P3a. An increase in D1/D2 receptor activation thus appears to potentiate neural sensitivity to novel stimuli, causing this content to be better encoded.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.