SynthesisPloS one2013
Identification of the tyrosine-protein phosphatase non-receptor type 2 as a rheumatoid arthritis susceptibility locus in europeans.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Identification of BACH2 and RAD51B as rheumatoid arthritis susceptibility loci in a meta-analysis of genome-wide data.Arthritis and rheumatism · 2013Pooled it
- Identification of potential key efferocytosis-related genes in rheumatoid arthritis using machine learning.Clinical rheumatology · 2026Article
- Platelets-related signature based diagnostic model in rheumatoid arthritis using WGCNA and machine learning.Frontiers in immunology · 2023Article
- Article
- T cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling.The Journal of clinical investigation · 2021Article
- PTPN2 Regulates Interactions Between Macrophages and Intestinal Epithelial Cells to Promote Intestinal Barrier Function.Gastroenterology · 2020Article
- Article
- The Role of Protein Tyrosine Phosphatases in Inflammasome Activation.International journal of molecular sciences · 2020Review
- Genome-wide DNA methylation analysis in primary antiphospholipid syndrome neutrophils.Clinical immunology (Orlando, Fla.) · 2018Article
- PTPN2 Downregulation Is Associated with Albuminuria and Vitamin D Receptor Deficiency in Type 2 Diabetes Mellitus.Journal of diabetes research · 2018Article
- Cardiovascular disease risk profiles in inflammatory joint disease entities.Arthritis research & therapy · 2017Article
- Update on the genetic architecture of rheumatoid arthritis.Nature reviews. Rheumatology · 2017Review
- Rheumatoid arthritis in an adult patient with mosaic distal 18q-, 18p- and ring chromosome 18.F1000Research · 2017Article
- Polymorphisms in STAT-4, IL-10, PSORS1C1, PTPN2 and MIR146A genes are associated differently with prognostic factors in Italian patients affected by rheumatoid arthritis.Clinical and experimental immunology · 2016Article
- [Treat to target and personalized medicine (precision medicine)].Zeitschrift fur Rheumatologie · 2016Review
- The genetics of rheumatoid arthritis: risk and protection in different stages of the evolution of RA.Rheumatology (Oxford, England) · 2016Review
- Genetic Variants of PTPN2 Gene in Chinese Children with Type 1 Diabetes Mellitus.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Kinetics of gene expression and bone remodelling in the clinical phase of collagen-induced arthritis.Arthritis research & therapy · 2015Article
Corrections and comments
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Authors and funding
25 authors at 14 institutions in 7 countries.
Funding
Abstract
objectivesGenome-wide association studies have facilitated the identification of over 30 susceptibility loci for rheumatoid arthritis (RA). However, evidence for a number of potential susceptibility genes have not so far reached genome-wide significance in studies of Caucasian RA.
methodsA cohort of 4286 RA patients from across Europe and 5642 population matched controls were genotyped for 25 SNPs, then combined in a meta-analysis with previously published data.
resultsSignificant evidence of association was detected for nine SNPs within the European samples. When meta-analysed with previously published data, 21 SNPs were associated with RA susceptibility. Although SNPs in the PTPN2 gene were previously reported to be associated with RA in both Japanese and European populations, we show genome-wide evidence for a different SNP within this gene associated with RA susceptibility in an independent European population (rs7234029, P = 4.4×10(-9)).
conclusionsThis study provides further genome-wide evidence for the association of the PTPN2 locus (encoding the T cell protein tyrosine phosphastase) with Caucasian RA susceptibility. This finding adds to the growing evidence for PTPN2 being a pan-autoimmune susceptibility gene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.