ArticlePloS one2013
Alterations of Neuromuscular Function after the World's Most Challenging Mountain Ultra-Marathon.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed, 129 citations in OpenAlex.
- Effect of the Fatigue Induced by a 110-km Ultramarathon on Tibial Impact Acceleration and Lower Leg Kinematics.PloS one · 2016Trial
- Lung function decline after mountain ultra-marathon is accompanied by reduced inspiratory pressure but not by detectable changes in CC16.European journal of applied physiology · 2026Article
- Musculoskeletal (Mal)adaptations in Response to a > 30 000-km Running Challenge.Journal of cachexia, sarcopenia and muscle · 2026Article
- Review
- Project FURTHER: A Physiological, Biomechanical, and Psychosocial Profile of an All-Female 6-Day Ultramarathon Race.Sports medicine - open · 2026Article
- Effects of extreme mountain ultramarathon on stress-related biomarkers from multiple biological matrices in adult male runners.Physiological reports · 2026Article
- Task Failure in Endurance Sports: A Review.Sports medicine (Auckland, N.Z.) · 2026Review
- Physiology of lived experience: Cruising among the Swiss peaks.Experimental physiology · 2026Article
- Muscle, Neuromuscular, and Cardiac Damage in Trail Running: A Systematic Review.Muscles (Basel, Switzerland) · 2026Review
- The impact of pole use on vertical cost of transport and foot force during uphill treadmill walking before and after a simulated trail running competition.European journal of applied physiology · 2026Article
- Case report: Elevation variability and pacing regulation in an elite half-marathon runner: a longitudinal case study.Frontiers in physiology · 2026Article
- Comment on: "Sports Dietitians Australia and Ultra Sports Science Foundation Joint Position Statement: A Practitioner Guide to the Prevention and Management of Exercise-Associated Gastrointestinal Perturbations and Symptoms".Sports medicine (Auckland, N.Z.) · 2025Article
- Change in elevation predicts 100 km ultra marathon performance.Scientific reports · 2025Article
- Longitudinal NMR-based Metabolomics Analysis of Male Mountain Ultramarathon Runners: New Perspectives for Athletes Monitoring and Injury Prevention.Sports medicine - open · 2025Article
- Accelerated Red Blood Cell Turnover Following Extreme Mountain Ultramarathon?Medicine and science in sports and exercise · 2025Article
- Pacing in ultra-marathon running: the Western States 100-mile endurance run 2006-2023.Scientific reports · 2025Article
- Profiling measures of muscle strength and power throughout a 156 km ultra-trail running event.Frontiers in sports and active living · 2025Article
- Jump performance and handgrip strength do not reflect acute fatigue in elite trail runners after the 2023 world trail running championship.Frontiers in sports and active living · 2025Article
- Sleep deprivation and recovery: Endurance racing as a novel model.European journal of sport science · 2024Article
- Recovery after Running an "Everesting" Mountain Ultramarathon.Life (Basel, Switzerland) · 2023Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the physiological consequences of the most challenging mountain ultra-marathon (MUM) in the world: a 330-km trail run with 24000 m of positive and negative elevation change. Neuromuscular fatigue (NMF) was assessed before (Pre-), during (Mid-) and after (Post-) the MUM in experienced ultra-marathon runners (n = 15; finish time = 122.43 hours ±17.21 hours) and in Pre- and Post- in a control group with a similar level of sleep deprivation (n = 8). Blood markers of muscle inflammation and damage were analyzed at Pre- and Post-. Mean ± SD maximal voluntary contraction force declined significantly at Mid- (-13±17% and -10±16%, P<0.05 for knee extensor, KE, and plantar flexor muscles, PF, respectively), and further decreased at Post- (-24±13% and -26±19%, P<0.01) with alteration of the central activation ratio (-24±24% and -28±34% between Pre- and Post-, P<0.05) in runners whereas these parameters did not change in the control group. Peripheral NMF markers such as 100 Hz doublet (KE: -18±18% and PF: -20±15%, P<0.01) and peak twitch (KE: -33±12%, P<0.001 and PF: -19±14%, P<0.01) were also altered in runners but not in controls. Post-MUM blood concentrations of creatine kinase (3719±3045 Ul·(1)), lactate dehydrogenase (1145±511 UI·L(-1)), C-Reactive Protein (13.1±7.5 mg·L(-1)) and myoglobin (449.3±338.2 µg·L(-1)) were higher (P<0.001) than at Pre- in runners but not in controls. Our findings revealed less neuromuscular fatigue, muscle damage and inflammation than in shorter MUMs. In conclusion, paradoxically, such extreme exercise seems to induce a relative muscle preservation process due likely to a protective anticipatory pacing strategy during the first half of MUM and sleep deprivation in the second half.
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Registered trials
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