ArticlePloS one2013
Systematic identification and characterization of novel human skin-associated genes encoding membrane and secreted proteins.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Effect of Gentamicin Ointment in Patients with Nagashima-type Palmoplantar Keratosis: A Double-blind Vehicle-controlled Study.Acta dermato-venereologica · 2021Trial
- Distinctive DNA sequence features define epigenetic longevity of inflammatory memory.Science (New York, N.Y.) · 2026Article
- The Genetic Landscape of Familial Pulmonary Fibrosis.American journal of respiratory and critical care medicine · 2023Article
- Biomarker Discovery for Meta-Classification of Melanoma Metastatic Progression Using Transfer Learning.Genes · 2022Article
- Structure and Dynamics of Human Chemokine CCL16-Implications for Biological Activity.Biomolecules · 2022Article
- The Adhesion G-Protein-Coupled Receptor GPR115/Cells · 2022Article
- TREM2 macrophages induced by human lipids drive inflammation in acne lesions.Science immunology · 2022Article
- Construction of the axolotl cell landscape using combinatorial hybridization sequencing at single-cell resolution.Nature communications · 2022Article
- AAGAB is an assembly chaperone regulating AP1 and AP2 clathrin adaptors.Journal of cell science · 2021Article
- Functional Specialization of Human Salivary Glands and Origins of Proteins Intrinsic to Human Saliva.Cell reports · 2020Article
- G protein-coupled receptorThe Journal of biological chemistry · 2020Article
- Small breast epithelial mucin promotes the invasion and metastasis of breast cancer cells via promoting epithelial‑to‑mesenchymal transition.Oncology reports · 2020Article
- GPR115 Contributes to Lung Adenocarcinoma Metastasis Associated With LAMC2 and Predicts a Poor Prognosis.Frontiers in oncology · 2020Article
- Azithromycin induces epidermal differentiation and multivesicular bodies in airway epithelia.Respiratory research · 2019Article
- Systematic screening and identification of novel psoriasis‑specific genes from the transcriptome of psoriasis‑like keratinocytes.Molecular medicine reports · 2019Article
- Ingenol mebutate induces a tumor cell-directed inflammatory response and antimicrobial peptides thereby promoting rapid tumor destruction and wound healing.European journal of medical research · 2018Article
- TMEM45A, SERPINB5 and p16INK4A transcript levels are predictive for development of high-grade cervical lesions.American journal of cancer research · 2016Article
- TMEM45A Is Dispensable for Epidermal Morphogenesis, Keratinization and Barrier Formation.PloS one · 2016Article
- METEORIN-LIKE is a cytokine associated with barrier tissues and alternatively activated macrophages.Clinical immunology (Orlando, Fla.) · 2015Article
- International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.Pharmacological reviews · 2015Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Through bioinformatics analyses of a human gene expression database representing 105 different tissues and cell types, we identified 687 skin-associated genes that are selectively and highly expressed in human skin. Over 50 of these represent uncharacterized genes not previously associated with skin and include a subset that encode novel secreted and plasma membrane proteins. The high levels of skin-associated expression for eight of these novel therapeutic target genes were confirmed by semi-quantitative real time PCR, western blot and immunohistochemical analyses of normal skin and skin-derived cell lines. Four of these are expressed specifically by epidermal keratinocytes; two that encode G-protein-coupled receptors (GPR87 and GPR115), and two that encode secreted proteins (WFDC5 and SERPINB7). Further analyses using cytokine-activated and terminally differentiated human primary keratinocytes or a panel of common inflammatory, autoimmune or malignant skin diseases revealed distinct patterns of regulation as well as disease associations that point to important roles in cutaneous homeostasis and disease. Some of these novel uncharacterized skin genes may represent potential biomarkers or drug targets for the development of future diagnostics or therapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.