ReviewDeutsches Arzteblatt international2013
Brain development during adolescence: neuroscientific insights into this developmental period.
Review in Deutsches Arzteblatt international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 161 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
161 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Adolescent Alcohol and Stress Exposure Rewires Key Cortical Neurocircuitry.Frontiers in neuroscience · 2022Pooled it
- A Systematic Review of Household and Family Alcohol Use and Childhood Neurodevelopmental Outcomes in Low- and Middle-Income Countries.Child psychiatry and human development · 2021Pooled it
- A Metacognitive Intervention for Children and Adolescents in Neuropediatric Care (Mio-Training): Protocol for a Randomized Controlled Trial.JMIR research protocols · 2026Trial
- Trial
- Daily exposure to either a high- or low-energy-dense snack food reduces its reinforcing value in adolescents.Obesity (Silver Spring, Md.) · 2017Trial
- Mental disorders in childhood or adolescence and subsequent comprehensive school achievement.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Relationship between shark meat intake and blood mercury concentration in Korean adolescents.Annals of occupational and environmental medicine · 2026Article
- Developmental Brain Network Trajectories Differentiate Resilience and Vulnerability to Psychosis in 22q11.2 Deletion Syndrome.Biological psychiatry global open science · 2026Article
- Emotional Profiles in Adolescents With ADHD: A Person-Centered Analysis of Emotion Regulation, Resilience, and Internalizing Symptoms.Alpha psychiatry · 2026Article
- Influence of cannabis potency on mental health outcomes among adolescents and young adults: scoping review.BJPsych open · 2026Review
- Multiplatform Morphometric Profiling of Whole-Brain, Cerebellar Subregional, and Thalamic Nuclei Alterations in Pediatric Migraine Without Aura.Diagnostics (Basel, Switzerland) · 2026Article
- Sex-specific alterations of intrinsic brain activity and functional connectivity in adolescent obsessive-compulsive disorder.Medical & biological engineering & computing · 2026Article
- Virtual Dementia in the Digital Age: Neurocognitive Mechanisms, Behavioural Impact and Public Health Implications of Technology Overuse.Annals of neurosciences · 2026Review
- Youth Soccer Participation and Brain Health Outcomes in Adolescent Athletes.JAMA network open · 2026Article
- The developmental trajectory of the social brain: A movie-based exploration from childhood to adolescence.Developmental cognitive neuroscience · 2026Article
- Genetic Architecture of Perivascular Space Morphology in the Pediatric Brain.bioRxiv : the preprint server for biology · 2026Article
- Potentially traumatic events and substance use do not predict changes in resting state functional connectivity in early adolescence.NeuroImage · 2026Article
- Adolescent residential mobility, local nasal inflammation, and adult susceptibility to the common cold.Brain, behavior, & immunity - health · 2026Article
- Adolescent envy-like social comparison stress induces HPA axis hypoactivity and anxiety in female mice: implications for somatic symptom disorder.Scientific reports · 2026Article
- Paediatric traumatic brain injury: unique population and unique challenges.Brain : a journal of neurology · 2026Review
101 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
- Commented on by
- Commented on byIn reply.2013
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdolescence is the phase of life between late childhood and adulthood. Typically, adolescents seek diversion, new experiences, and strong emotions, sometimes putting their health at serious risk. In Germany, for example, 62% of all deaths among persons aged 15 to 20 are due to traumatic injuries. Neuroscientific explanations have been proposed for typical adolescent behavior; with these explanations in mind, one can derive appropriate ways of dealing with adolescents.
methodWe selectively review pertinent articles retrieved from the PubMed database about the structural and functional development of the brain in adolescence.
resultsNew findings in developmental psychology and neuroscience reveal that a fundamental reorganization of the brain takes place in adolescence. In postnatal brain development, the maximum density of gray matter is reached first in the primary sensorimotor cortex, and the prefrontal cortex matures last. Subcortical brain areas, especially the limbic system and the reward system, develop earlier, so that there is an imbalance during adolescence between the more mature subcortical areas and less mature prefrontal areas. This may account for typical adolescent behavior patterns, including risk-taking.
conclusionThe high plasticity of the adolescent brain permits environmental influences to exert particularly strong effects on cortical circuitry. While this makes intellectual and emotional development possible, it also opens the door to potentially harmful influences.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.