ArticleFrontiers in immunology2013
Monitoring the Dynamics of T Cell Clonal Diversity Using Recombinant Peptide:MHC Technology.
Article in Frontiers in immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Relationship of 2D Affinity to T Cell Functional Outcomes.International journal of molecular sciences · 2020Review
- The Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes.Frontiers in immunology · 2020Review
- 2D Kinetic Analysis of TCR and CD8 Coreceptor for LCMV GP33 Epitopes.Frontiers in immunology · 2018Article
- NFM Cross-Reactivity to MOG Does Not Expand a Critical Threshold Level of High-Affinity T Cells Necessary for Onset of Demyelinating Disease.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Heterogeneity assessment of functional T cell avidity.Scientific reports · 2017Article
- Adenovirus Serotype 5 Vaccination Results in Suboptimal CD4 T Helper 1 Responses in Mice.Journal of virology · 2017Article
- A Simple and Rapid Method for Quality Control of Major Histocompatibility Complex-Peptide Monomers by Flow Cytometry.Frontiers in immunology · 2017Article
- pMHC affinity controls duration of CD8+ T cell-DC interactions and imprints timing of effector differentiation versus expansion.The Journal of experimental medicine · 2016Article
- How many TCR clonotypes does a body maintain?Journal of theoretical biology · 2016Article
- Cutting Edge: Resident Memory CD8 T Cells Express High-Affinity TCRs.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Peptide ligand structure and I-Aq binding avidity influence T cell signaling pathway utilization.Clinical immunology (Orlando, Fla.) · 2015Article
- Lower Affinity T Cells are Critical Components and Active Participants of the Immune Response.Frontiers in immunology · 2015Review
- Progression of relapsing-remitting demyelinating disease does not require increased TCR affinity or epitope spread.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- TCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Bench, bedside, toolbox: T-cells deliver on every level.Frontiers in immunology · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The capacity to probe antigen specific T cells within the polyclonal repertoire has been revolutionized by the advent of recombinant peptide:MHC (pMHC) technology. Monomers and multimers of pMHC molecules can enrich for and identify antigen specific T cells to elucidate the contributions of T cell frequency, localization, and T cell receptor (TCR) affinity during immune responses. Two-dimensional (2D) measurements of TCR-pMHC interactions are at the forefront of this field because the biological topography is replicated such that TCR and pMHC are membrane anchored on opposing cells, allowing for biologically pertinent measures of TCR antigen specificity and diversity. 2D measurements of TCR-pMHC kinetics have also demonstrated increased fidelity compared to three-dimensional surface plasmon resonance data and are capable of detecting T cell affinities that are below the detection level of most pMHC multimers. Importantly, 2D techniques provide a platform to evaluate T cell affinity and antigen specificity against multiple protein epitopes within the polyclonal repertoire directly ex vivo from sites of ongoing immune responses. This review will discuss how antigen specific pMHC molecules, with a focus on 2D technologies, can be used as effective tools to evaluate the range of TCR affinities that comprise an immune response and more importantly how the breadth of affinities determine functional outcome against a given exposure to antigen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.