ArticleWorld journal of gastroenterology2013
Assessment of vascular invasion in gastric cancer: a comparative study.
Article in World journal of gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Development and temporal validation of preoperative and combined preoperative-pathological models for lymph node metastasis in early gastric cancer.Frontiers in oncology · 2026Article
- Vessel invasion is a risk factor for gastric cancer: a retrospective analysis study.World journal of surgical oncology · 2024Article
- Article
- Prediction of lymphovascular invasion of gastric cancer based on contrast-enhanced computed tomography radiomics.Frontiers in oncology · 2024Article
- Preoperative prediction of vessel invasion in locally advanced gastric cancer based on computed tomography radiomics and machine learning.Oncology letters · 2023Article
- Application of Parametric Shared Frailty Models to Analyze Time-to-Death of Gastric Cancer Patients.Journal of gastrointestinal cancer · 2023Article
- Evaluation of Lymphovascular Invasion by CD31 Expression in Gastric Adenocarcinoma.Iranian journal of pathology · 2023Article
- Nomograms predicting prognosis of patients with pathological stages T1N2-3 and T3N0 gastric cancer.World journal of gastrointestinal surgery · 2022Article
- Elevated Serum Alpha-Fetoprotein Is a Significant Prognostic Factor for Patients with Gastric Cancer: Results Based on a Large-Scale Retrospective Study.Frontiers in oncology · 2022Article
- Issues of origin, morphology and clinical significance of tumor microvessels in gastric cancer.World journal of gastroenterology · 2021Review
- Cancer cells invasion to the gastric bare area adipose tissue: a poor prognostic predictor for gastric cancer.World journal of surgical oncology · 2020Article
- Three-dimensional visualization of cleared human pancreas cancer reveals that sustained epithelial-to-mesenchymal transition is not required for venous invasion.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020Article
- Long-term outcomes after non-curative endoscopic submucosal dissection for early gastric cancer according to hospital volumes in Japan: a multicenter propensity-matched analysis.Surgical endoscopy · 2019Article
- Prognostic significance of lymphovascular infiltration in overall survival of gastric cancer patients after surgery with curative intent.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2019Article
- CT volumetry for gastric adenocarcinoma: association with lymphovascular invasion and T-stages.Oncotarget · 2018Article
- Association between spectral computed tomography images and clinicopathological features in advanced gastric adenocarcinoma.Oncology letters · 2017Article
- Relationship between expression of NADPH oxidase 2 and invasion and prognosis of human gastric cancer.World journal of gastroenterology · 2015Article
- The prognostic significance of lymphovascular invasion in patients with resectable gastric cancer: a large retrospective study from Southern China.BMC cancer · 2015Article
- Vascular invasion as an independent predictor of poor prognosis in nonmetastatic gastric cancer after curative resection.International journal of clinical and experimental pathology · 2015Article
- Evaluation of Gastric Carcinomas Histological Patterns in Relation to Tumors Aggressiveness Parameters.Current health sciences journalArticle
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5 authors.
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Abstract
aimTo evaluate and compare detection of lymphatic and blood vessel invasion (LVI and BVI) by hematoxylin-eosin (HE) and immunohistochemistry (IHC) in gastric cancer specimens, and to correlate with lymph node status.
methodsIHC using D2-40 (a lymphatic endothelial marker) and CD34 (a pan-endothelial marker) was performed to study LVI and BVI in surgical specimens from a consecutive series of 95 primary gastric cancer cases. The results of the IHC study were compared with the detection by HE using McNemar test and kappa index. The morphologic features of the tumors and the presence of LVI and BVI were related to the presence of lymph node metastasis. A χ(2) test was performed to obtain associations between LVI and BVI and other prognostic factors for gastric cancer.
resultsThe detection rate of LVI was considerably higher than that of BVI. The IHC study identified eight false-positive cases and 13 false-negative cases for LVI, and 24 false-positive cases and 10 false-negative cases for BVI. The average Kappa value determined was moderate for LVI (κ = 0.50) and low for BVI (κ = 0.20). Both LVI and BVI were statistically associated with the presence of lymph node metastasis (HE: P = 0.001, P = 0.013, and IHC: P = 0.001, P = 0.019). The morphologic features associated with LVI were location of the tumor in the distal third of the stomach (P = 0.039), Borrmann's macroscopic type (P = 0.001), organ invasion (P = 0.03) and the depth of tumor invasion (P = 0.001). The presence of BVI was related only to the depth of tumor invasion (P = 0.003).
conclusionThe immunohistochemical identification of lymphatic and blood vessels is useful for increasing the accuracy of the diagnosis of vessel invasion and for predicting lymph node metastasis.
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