ReviewMediators of inflammation2013
Neurovascular unit in chronic pain.
Review in Mediators of inflammation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- Review
- Unique RNA Gene Expression Profile Is Seen in Chronic Non-Specific Low Back Pain.International journal of molecular sciences · 2025Article
- Bioguided Isolation of Alkaloids and Pharmacological Effects of the Total Alkaloid Fraction fromPlants (Basel, Switzerland) · 2021Article
- Changes in blood-spinal cord barrier permeability and neuroimmune interactions in the underlying mechanisms of chronic pain.Pain reports · 2021Review
- Have We Looked in the Wrong Direction for More Than 100 Years? Delayed Onset Muscle Soreness Is, in Fact, Neural Microdamage Rather Than Muscle Damage.Antioxidants (Basel, Switzerland) · 2020Article
- Anti-Inflammatory and Antioxidant Activity of Pollen Extract Collected byAntioxidants (Basel, Switzerland) · 2020Article
- The effect of endurance training and testosterone supplementation on the expression of blood spinal cord barrier proteins in rats.PloS one · 2019Article
- Polymethoxyflavones fromFrontiers in pharmacology · 2018Article
- Dysfunction of the neurovascular unit in ischemic stroke and neurodegenerative diseases: An aging effect.Ageing research reviews · 2017Review
- Antinociceptive effect of methanol extract of Dalbergia sissoo leaves in mice.BMC complementary and alternative medicine · 2017Article
- Gene expression comparison reveals distinct basal expression of HOX members and differential TNF-induced response between brain- and spinal cord-derived microvascular endothelial cells.Journal of neuroinflammation · 2016Article
- Salmon-derived thrombin inhibits development of chronic pain through an endothelial barrier protective mechanism dependent on APC.Biomaterials · 2016Article
- Roads Less Traveled: Sexual Dimorphism and Mast Cell Contributions to Migraine Pathology.Frontiers in immunology · 2016Review
- The Neuroprotective Effect of Tetramethylpyrazine Against Contusive Spinal Cord Injury by Activating PGC-1α in Rats.Neurochemical research · 2015Article
- The role of the blood-brain barrier in the development and treatment of migraine and other pain disorders.Frontiers in cellular neuroscience · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic pain is a debilitating condition with major socioeconomic impact, whose neurobiological basis is still not clear. An involvement of the neurovascular unit (NVU) has been recently proposed. In particular, the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB), two NVU key players, may be affected during the development of chronic pain; in particular, transient permeabilization of the barrier is suggested by several inflammatory- and nerve-injury-based pain models, and we argue that the clarification of molecular BBB/BSCB permeabilization events will shed new light in understanding chronic pain mechanisms. Possible biases in experiments supporting this theory and its translational potentials are discussed. Moving beyond an exclusive focus on the role of the endothelium, we propose that our understanding of the mechanisms subserving chronic pain will benefit from the extension of research efforts to the NVU as a whole. In this view, the available evidence on the interaction between analgesic drugs and the NVU is here reviewed. Chronic pain comorbidities, such as neuroinflammatory and neurodegenerative diseases, are also discussed in view of NVU changes, together with innovative pharmacological solutions targeting NVU components in chronic pain treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.