ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2013
Excess risk of Clostridium difficile infection in ovarian cancer is related to exposure to broad-spectrum antibiotics.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 15 citations in OpenAlex.
- Metabolism-Driven Modulation by the Human Microbiota: Implications for Cancer Therapy and Emerging Strategies.Advances in experimental medicine and biology · 2026Review
- Potential Role of Vaginal Microbiota in Ovarian Cancer Carcinogenesis, Progression and Treatment.Pharmaceutics · 2023Review
- Jujube Powder Enhances Cyclophosphamide Efficiency against Murine Colon Cancer by Enriching CD8Nutrients · 2021Article
- Microbiota-Host-Irinotecan Axis: A New Insight Toward Irinotecan Chemotherapy.Frontiers in cellular and infection microbiology · 2021Review
- Fecal microbiota transplantation in cancer management: Current status and perspectives.International journal of cancer · 2019Review
- Gut microbiota modulation of chemotherapy efficacy and toxicity.Nature reviews. Gastroenterology & hepatology · 2017Review
- Risks factors and outcomes of Clostridium difficile infection in patients with cancer: a matched case-control study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Article
- Importance of Molecular Methods to Determine Whether a Probiotic is the Source of Lactobacillus Bacteremia.Probiotics and antimicrobial proteins · 2016Article
- Using a Novel Lysin To Help Control Clostridium difficile Infections.Antimicrobial agents and chemotherapy · 2015Article
- Risk factors associated with Clostridium difficile infection in adult oncology patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2015Article
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Authors and funding
6 authors at 1 institution.
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No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of the study was to determine if a diagnosis of ovarian cancer is independently associated with an increased risk of Clostridium difficile infection (CDI).
methodsThe University HealthSystem Consortium database was queried to perform a retrospective cohort study of women with and without ovarian cancer who were diagnosed with CDI. Inpatients undergoing total hysterectomy from 2008 to 2012 were studied. Ovarian cancer patients were compared to non-ovarian cancer patients to evaluate relative risk (RR) of CDI. Adjustment was made for known or suspected CDI risk factors to determine RR of CDI independent of these variables.
resultsIn this study, 115,203 patients were included. CDI was reported in 0.80 % of ovarian cancer patients and in 0.31 % of non-ovarian cancer patients (RR = 2.50; 95 % confidence interval (CI) = 2.02 to 3.35). Stratification by age, presence of other comorbidities, or administration of antineoplastic drugs did not significantly modify the elevated risk associated with ovarian cancer. Significantly increased risk in ovarian cancer patients was no longer observed after controlling for broad-spectrum antibiotic administration (RR = 1.28, 95 % CI = 0.39 to 4.13). Compared to non-ovarian cancer patients, ovarian cancer patients were more frequently treated with broad-spectrum antibiotics, had a 39 % longer mean duration of therapy, and had 2.5-fold greater mean total exposure to broad-spectrum antibiotics.
conclusionsAfter adjustment for antibiotic use, ovarian cancer patients are not at excess risk of CDI. Additional studies are needed to understand the patterns of broad-spectrum antibiotic prescription for ovarian cancer patients leading to increased exposure. If feasible, reduction of this exposure may decrease morbidity in this population.
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