ReviewPsychopharmacology2014
The utility of patient specific induced pluripotent stem cells for the modelling of Autistic Spectrum Disorders.
Review in Psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed.
- Alzheimer's disease brain-derived tau extracts show differential processing and transcriptional effects in human astrocytes.iScience · 2025Article
- Cell line specific alterations in genes associated with dopamine metabolism and signaling in midbrain dopaminergic neurons derived from 22q11.2 deletion carriers with elevated dopamine synthesis capacity.Schizophrenia research · 2024Article
- Glycosylated clusterin species facilitate Aβ toxicity in human neurons.Scientific reports · 2022Article
- Attenuated transcriptional response to pro-inflammatory cytokines in schizophrenia hiPSC-derived neural progenitor cells.Brain, behavior, and immunity · 2022Article
- Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons.Molecular brain · 2021Article
- Generation of an iPSC line (CRICKi001-A) from an individual with a germline SMARCA4 missense mutation and autism spectrum disorder.Stem cell research · 2021Article
- Dopamine-induced interactions of female mouse hypothalamic proteins with progestin receptor-A in the absence of hormone.Journal of neuroendocrinology · 2020Article
- Interferon-γ signaling in human iPSC-derived neurons recapitulates neurodevelopmental disorder phenotypes.Science advances · 2020Article
- Unexpectedly High Levels of Inverted Re-Insertions Using Paired sgRNAs for Genomic Deletions.Methods and protocols · 2020Article
- The sociability spectrum: evidence from reciprocal genetic copy number variations.Molecular autism · 2020Review
- Copy number variants (CNVs): a powerful tool for iPSC-based modelling of ASD.Molecular autism · 2020Review
- Apolipoprotein E expression pattern in human induced pluripotent stem cells duringF1000Research · 2020Article
- Single-molecule fluorescence in-situ hybridization reveals that human SHANK3 mRNA expression varies during development and in autism-associated SHANK3 heterozygosity.Stem cell research & therapy · 2018Article
- Stem cell-derived neurons from autistic individuals with SHANK3 mutation show morphogenetic abnormalities during early development.Molecular psychiatry · 2018Article
- Understanding the role of steroids in typical and atypical brain development: Advantages of using a "brain in a dish" approach.Journal of neuroendocrinology · 2018Review
- Clusterin Is Required for β-Amyloid Toxicity in Human iPSC-Derived Neurons.Frontiers in neuroscience · 2018Article
- Glaucoma, Stem Cells, and Gene Therapy: Where Are We Now?International journal of stem cells · 2017Review
- Human induced pluripotent stem cells as a research tool in Alzheimer's disease.Psychological medicine · 2017Review
- Psychosis Risk Candidate ZNF804A Localizes to Synapses and Regulates Neurite Formation and Dendritic Spine Structure.Biological psychiatry · 2017Article
- The EU-AIMS Longitudinal European Autism Project (LEAP): design and methodologies to identify and validate stratification biomarkers for autism spectrum disorders.Molecular autism · 2017Observational
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Until now, models of psychiatric diseases have typically been animal models. Whether they were to be used to further understand the pathophysiology of the disorder, or as drug discovery tools, animal models have been the choice of preference in mimicking psychiatric disorders in an experimental setting. While there have been cellular models, they have generally been lacking in validity. This situation is changing with the advent of patient-specific induced pluripotent stem cells (iPSCs). In this article, we give a methodological evaluation of the current state of the iPS technology with reference to our own work in generating patient-specific iPSCs for the study of autistic spectrum disorder (ASD). In addition, we will give a broader perspective on the validity of this technology and to what extent it can be expected to complement animal models of ASD in the coming years.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.