Evidence map›Paper›PMID 23839063›Full record

ArticleMucosal immunology2014

Abnormal apical-to-basal transport of dietary ovalbumin by secretory IgA stimulates a mucosal Th1 response.

J Abed, C Lebreton, G Champier, A Cuvillier, M Cogné, B Meresse, C Dugave, M Garfa-Traoré, B Corthésy, N Cerf-Bensussan and 1 more

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Mucosal immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Tear fluid participates in systemic immunity.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

J Abed1] Institut National de la Santé et de la Recherche Médicale (INSERM), UMR989, Paris, France [2] Université Paris Descartes-Sorbonne Paris Cité, Institut IMAGINE, Paris, France.
C Lebreton1] Institut National de la Santé et de la Recherche Médicale (INSERM), UMR989, Paris, France [2] Université Paris Descartes-Sorbonne Paris Cité, Institut IMAGINE, Paris, France.
G ChampierB Cell Design, rue C. Legendre, Limoges, France.
A CuvillierB Cell Design, rue C. Legendre, Limoges, France.
M CognéCNRS, UMR6101 Université de Limoges, Limoges, France.
B Meresse1] Institut National de la Santé et de la Recherche Médicale (INSERM), UMR989, Paris, France [2] Université Paris Descartes-Sorbonne Paris Cité, Institut IMAGINE, Paris, France.
C DugaveCommissariat à l'Énergie Atomique, iBiTecS, Service d'Ingénierie Moléculaire des Protéines, Gif-sur-Yvette, France.
M Garfa-Traoré1] Université Paris Descartes-Sorbonne Paris Cité, Institut IMAGINE, Paris, France [2] IFR 94, Imagery platform, Paris, France.
B CorthésyR&D Laboratory, Division of Immunology and Allergy, University State Hospital (CHUV), Lausanne, Switzerland.
N Cerf-Bensussan1] Institut National de la Santé et de la Recherche Médicale (INSERM), UMR989, Paris, France [2] Université Paris Descartes-Sorbonne Paris Cité, Institut IMAGINE, Paris, France.
M Heyman1] Institut National de la Santé et de la Recherche Médicale (INSERM), UMR989, Paris, France [2] Université Paris Descartes-Sorbonne Paris Cité, Institut IMAGINE, Paris, France.
Délégation Paris 5 · FRCentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In celiac disease, enhanced permeability to gliadin peptides can result from their apico-basal transport by secretory immunoglobulin A1 (SIgA1) binding to the CD71 receptor ectopically expressed at the gut epithelial surface. Herein, we have established a mouse model in which there is apico-basal transport of the model antigen ovalbumin (OVA) by specific SIgA1 and have analyzed local T-cell activation. Transgenic DO11.10 mice were grafted with a hybridoma-secreting OVA-specific humanized IgA1, which could bind mouse CD71 and which were released in the intestinal lumen as SIgA. CD71 expression was induced at the gut apical surface by treating the mice with tyrphostin A8. Following gavage of the mice with OVA, OVA-specific CD4⁺ T cells isolated from the mesenteric lymph nodes displayed higher expression of the activation marker CD69 and produced more interferon gamma in mice bearing the hybridoma-secreting OVA-specific IgA1, than in ungrafted mice or in mice grafted with an irrelevant hybridoma. These results indicate that the protective role of SIgA1 might be jeopardized in human pathological conditions associated with ectopic expression of CD71 at the gut surface.

Indexed as

AnimalsAntigens, CDCD4-Positive T-LymphocytesCeliac DiseaseDisease Models, AnimalEnterocytesFemaleHumansImmunoglobulin A, SecretoryIntestinal MucosaLymph NodesMesenteryMiceMice, TransgenicOvalbuminProtein BindingAntigens, CDCD71 antigenImmunoglobulin A, SecretoryOvalbuminReceptors, TransferrinTyrphostins

Identifiers

PMID23839063
OpenAlexW2060800807

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.