ArticlePlanta2013
Fusaric acid induction of programmed cell death modulated through nitric oxide signalling in tobacco suspension cells.
Article in Planta, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 46 citations in OpenAlex.
- Phenolic Compounds Accumulation and Cell Death Degree Induced by Fusaric Acid in Agroforestry Hosts Plants ofJournal of fungi (Basel, Switzerland) · 2025Article
- Fusaric acid-mediated S-glutathionylation of MaAKT1 channel confers the virulence of Foc TR4 to banana.PLoS pathogens · 2025Article
- Fusaric acid-evoked oxidative stress affects plant defence system by inducing biochemical changes at subcellular level.Plant cell reports · 2023Review
- Research progress and management strategies of fungal diseases inFrontiers in microbiology · 2023Review
- Pre-selection of banana somaclones resistant toCrop protection (Guildford, Surrey) · 2021Article
- Article
- Concise Total Synthesis and Antifungal Activities of Fusaric Acid, a Natural Product.Molecules (Basel, Switzerland) · 2020Article
- Fusaric acid instigates the invasion of banana by Fusarium oxysporum f. sp. cubense TR4.The New phytologist · 2020Article
- Genetic Diversity inFrontiers in plant science · 2019Article
- Environmental pH modulates transcriptomic responses in the fungus Fusarium sp. associated with KSHB Euwallacea sp. near fornicatus.BMC genomics · 2018Article
- Fusaric acid contributes to virulence of Fusarium oxysporum on plant and mammalian hosts.Molecular plant pathology · 2018Article
- Microbial Resistance Mechanisms to the Antibiotic and Phytotoxin Fusaric Acid.Journal of chemical ecology · 2017Article
- NO and HEnvironmental science and pollution research international · 2017Article
- A Rapid Method with UPLC for the Determination of Fusaric Acid inIndian journal of microbiology · 2017Article
- The relationship between vacuolation and initiation of PCD in rice (Oryza sativa) aleurone cells.Scientific reports · 2017Article
- Mechanisms of thaxtomin A-induced root toxicity revealed by a thaxtomin A sensitive Arabidopsis mutant (ucu2-2/gi-2).Plant cell reports · 2016Article
- Conversion of fusaric acid to Fusarinol by Aspergillus tubingensis: a detoxification reaction.Journal of chemical ecology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fusaric acid (FA) is a nonhost-selective toxin mainly produced by Fusarium oxysporum, the causal agent of plant wilt diseases. We demonstrate that FA can induce programmed cell death (PCD) in tobacco suspension cells and the FA-induced PCD is modulated by nitric oxide (NO) signalling. Cells undergoing cell death induced by FA treatment exhibited typical characteristics of PCD including cytoplasmic shrinkage, chromatin condensation, DNA fragmentation, membrane plasmolysis, and formation of small cytoplasmic vacuoles. In addition, caspase-3-like activity was activated upon the FA treatment. The process of FA-induced PCD was accompanied by a rapid accumulation of NO in a FA dose-dependent manner. Pre-treatment of cells with NO scavenger 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (cPTIO) or NO synthase inhibitor N(G)-monomethyl-arginine monoacetate (L-NMMA) significantly reduced the rate of FA-induced cell death. Furthermore, the caspase-3-like activity and the expression of PAL and Hsr203J genes were alleviated by application of cPTIO or L-NMMA to FA-treated tobacco cells. This indicates that NO is an important factor involved in the FA-induced PCD. Our results also show that pre-treatment of tobacco cells with a caspase-3-specific inhibitor, Ac-DEVD-CHO, can reduce the rate of FA-induced cell death. These results demonstrate that the FA-induced cell death is a PCD and is modulated by NO signalling through caspase-3-like activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.