ArticleHead and neck pathology2014
Small cell neuroendocrine carcinoma of the oropharynx harbouring oncogenic HPV-infection.
Article in Head and neck pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Human papillomavirus status and prognosis of oropharyngeal high-grade neuroendocrine carcinoma.Oral oncology · 2023Review
- Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Oropharynx and Nasopharynx.Head and neck pathology · 2022Review
- Human Papillomavirus-Associated Oropharyngeal High-Grade Neuroendocrine Carcinoma in an Adolescent: Case Report and Review of Literature.Clinical medicine insights. Pediatrics · 2019Article
- Epstein-Barr Virus-Positive Large Cell Neuroendocrine Carcinoma of the Nasopharynx: Report of a Case with Complete Clinical and Radiological Response After Combined Chemoradiotherapy.Head and neck pathology · 2018Article
- The First Report of Small Cell Cancer of the Uvula Presenting With Ectopic Adrenocorticotropic Hormone Syndrome.World journal of oncology · 2018Article
- A robust response to combination immune checkpoint inhibitor therapy in HPV-related small cell cancer: a case report.Journal for immunotherapy of cancer · 2018Article
- Tonsillar Small Cell Carcinoma: Potential Contribution of Human Papillomavirus.The American journal of case reports · 2018Article
- Squamous and Neuroendocrine Specific Immunohistochemical Markers in Head and Neck Squamous Cell Carcinoma: A Tissue Microarray Study.Head and neck pathology · 2018Article
- Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Oropharynx.Head and neck pathology · 2017Article
- Morphologic diversity in human papillomavirus-related oropharyngeal squamous cell carcinoma: Catch Me If You Can!Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2017Review
- p16 overexpression in high-grade neuroendocrine carcinomas of the head and neck: potential diagnostic pitfall with HPV-related carcinomas.Virchows Archiv : an international journal of pathology · 2016Article
- Small cell neuroendocrine carcinoma of tracheostomy site in a patient with a history of juvenile laryngeal papillomatosis.BMJ case reports · 2016Article
- Biphenotypic human papillomavirus-associated head and neck squamous cell carcinoma: a report of two cases.Diagnostic pathology · 2015Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small cell carcinoma/neuroendocrine carcinoma (SCNEC) of the oropharynx is uncommon. Recently, an association has been reported between oropharyngeal SCNEC and high-risk human papillomavirus (HPV) infection. While HPV infection confers a better prognosis for oropharyngeal squamous cell carcinoma, HPV infection does not appear to influence the biological behaviour of SCNECs, which are generally associated with poor clinical outcomes. We document two cases of SCNEC arising in the oropharynx with evidence of high-risk HPV infection. The cases highlight the expanding range of malignant oropharyngeal neoplasms that harbour oncogenic HPV infection and support the concept that, irrespective of HPV infection, neuroendocrine differentiation portends a poor prognosis.
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