ArticleJournal of neurovirology2013
Increases in brain white matter abnormalities and subcortical gray matter are linked to CD4 recovery in HIV infection.
Article in Journal of neurovirology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Different roles of frontal versus striatal atrophy in HIV-associated neurocognitive disorders.Human brain mapping · 2019Pooled it
- Cortical White and Grey Matter Volume Differences Associated with Plasma Cytokine and Chemokine Levels in PLWH in Cape Town.International journal of molecular sciences · 2025Article
- Determinants of Brain Atrophy in People Living with HIV: The Role of Lifestyle, Demographics, and Comorbidities.Journal of clinical medicine · 2025Article
- The prefrontal cortex, but not the medial temporal lobe, is associated with episodic memory in middle-aged persons with HIV.Journal of the International Neuropsychological Society : JINS · 2024Article
- A longitudinal study of the brain structure network changes in HIV patients with ANI: combined VBM with SCN.Frontiers in neurology · 2024Article
- Elevated Plasma Protein Carbonyl Concentration Is Associated with More Abnormal White Matter in People with HIV.Viruses · 2023Article
- Chronic brain damage in HIV-infected individuals under antiretroviral therapy is associated with viral reservoirs, sulfatide release, and compromised cell-to-cell communication.Cellular and molecular life sciences : CMLS · 2023Article
- Characterization of basal ganglia volume changes in the context of HIV and polysubstance use.Scientific reports · 2022Article
- Associations of alcohol use, HIV infection, and age with brain white matter microstructure.Journal of neurovirology · 2021Article
- Higher CSF Ferritin Heavy-Chain (Fth1) and Transferrin Predict Better Neurocognitive Performance in People with HIV.Molecular neurobiology · 2021Observational
- Confound, Cause, or Cure: The Effect of Cannabinoids on HIV-Associated Neurological Sequelae.Viruses · 2021Review
- Iron-regulatory genes are associated with Neuroimaging measures in HIV infection.Brain imaging and behavior · 2020Article
- Brain structural correlates of trajectories to cognitive impairment in men with and without HIV disease.Brain imaging and behavior · 2020Article
- Use of Neuroimaging to Inform Optimal Neurocognitive Criteria for Detecting HIV-Associated Brain Abnormalities.Journal of the International Neuropsychological Society : JINS · 2020Article
- Effects of comorbidity burden and age on brain integrity in HIV.AIDS (London, England) · 2019Observational
- Semaphorin4A causes loss of mature oligodendrocytes and demyelination in vivo.Journal of neuroinflammation · 2019Article
- White matter damage, neuroinflammation, and neuronal integrity in HAND.Journal of neurovirology · 2019Article
- Neuroanatomical Changes Underlying Vertical HIV Infection in Adolescents.Frontiers in immunology · 2019Article
- Mapping abnormal subcortical neurodevelopment in a cohort of Thai children with HIV.NeuroImage. Clinical · 2019Article
- Semaphorin4A and H-ferritin utilize Tim-1 on human oligodendrocytes: A novel neuro-immune axis.Glia · 2018Article
Corrections and comments
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Authors and funding
24 authors at 6 institutions in 1 country.
Funding
Abstract
MRI alterations in the cerebral white (WM) and gray matter (GM) are common in HIV infection, even during successful combination antiretroviral therapy (CART), and their pathophysiology and clinical significance are unclear. We evaluated the association of these alterations with recovery of CD4+ T cells. Seventy-five HIV-infected (HIV+) volunteers in the CNS HIV Anti-Retroviral Therapy Effects Research study underwent brain MRI at two visits. Multi-channel morphometry yielded volumes of total cerebral WM, abnormal WM, cortical and subcortical GM, and ventricular and sulcal CSF. Multivariable linear regressions were used to predict volumetric changes with change in current CD4 and detectable HIV RNA. On average, the cohort (79 % initially on CART) demonstrated loss of total cerebral WM alongside increases in abnormal WM and ventricular volumes. A greater extent of CD4 recovery was associated with increases in abnormal WM and subcortical GM volumes. Virologic suppression was associated with increased subcortical GM volume, independent of CD4 recovery. These findings suggest a possible link between brain alterations and immune recovery, distinct from the influence of virologic suppression. The association of increasing abnormal WM and subcortical GM volumes with CD4+ T cell recovery suggests that neuroinflammation may be one mechanism in CNS pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.