ArticleJournal of assisted reproduction and genetics2013
Vitrification of blastocysts derived from fair to poor quality cleavage stage embryos can produce high pregnancy rates after warming.
Article in Journal of assisted reproduction and genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- In vitro fertilization for women infected by hepatitis C virus: a matched case-control study and a systematic literature review.Journal of assisted reproduction and genetics · 2017Pooled it
- Increased live births after day 5 versus day 6 transfers of vitrified-warmed blastocysts.Journal of assisted reproduction and genetics · 2018Trial
- Single frozen-thawed blastocyst derived from poor-grade Day 3 embryo is not associated with adverse neonatal outcomes: a retrospective cohort study.Archives of gynecology and obstetrics · 2025Article
- Clinical outcomes of frozen-thawed single blastocyst transfer derived from low-quality day 3 embryos: A retrospective cohort study.Frontiers in endocrinology · 2025Article
- Dual laser-assisted hatching: an effective technique to salvage low-grade cleavage-stage embryos and harvest day 7 blastocysts.Lasers in medical science · 2023Article
- Clinical Outcome of Day-3 Cleavage Slow-Growing Embryos at Different Cleavage Rates after Overnight Culture: A Cohort Retrospective Study.Journal of clinical medicine · 2022Article
- Disposition of embryos from women who only produced morphologically poor embryos on day three.Biomedical journal · 2022Observational
- Laser-assisted hatching in lower grade cleavage stage embryos improves blastocyst formation: results from a retrospective study.Journal of ovarian research · 2021Article
- Improving the clinical outcomes by extended culture of day 3 embryos with low blastomere number to blastocyst stage following frozen-thawed embryo transfer.Archives of gynecology and obstetrics · 2021Article
- Miscarriage Rate Is High With Frozen-Thawed Blastocysts Arising From Poor-Quality Cleavage Stage Embryos.Frontiers in endocrinology · 2020Article
- Extended culture of poor-quality supernumerary embryos improves ART outcomes.Journal of assisted reproduction and genetics · 2018Article
- The impact of paternal factors on cleavage stage and blastocyst development analyzed by time-lapse imaging-a retrospective observational study.Journal of assisted reproduction and genetics · 2015Observational
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study investigates whether certain embryos considered unsuitable for cryopreservation on day 3 might nevertheless have the potential to develop into worthwhile blastocysts that could be vitrified in the same cycle.
methodsRetrospective study: between 2010 and 2011, embryo transfers and cryopreservation took place mainly on day 3 in our centre. Supernumerary embryos of intermediate to poor quality were reassessed on days 5/6 and any good quality blastocysts were vitrified.
resultsOut of 914 cleavage stage (day 3) embryos left in culture, 16 % were vitrified on days 5/6. Fifty blastocyst warming cycles resulted in a 76 % survival rate, 44 % clinical pregnancy rate and 39 % implantation rate. During the same time period, 213 warming cycles of good quality cleavage stage embryos rendered survival rates, clinical pregnancy and implantation rates of 97 %, 23 % and 16 % respectively.
conclusionsSupernumerary average quality day 3 embryos should be given a second chance to be selected for cryopreservation. If blastocysts are obtained and survive vitrification, there is a good chance of implantation thus reducing embryo waste.
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