Evidence map›Paper›PMID 23838642›Full record

ReviewCurrent opinion in organ transplantation2013

Memory T cells in transplantation - progress and challenges.

Xian C Li, Malgosia Kloc, Rafik M Ghobrial

Abstract readReview
In one paragraph

Review in Current opinion in organ transplantation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Engineered Cell-Based Therapeutics: Synthetic Biology Meets Immunology.Frontiers in bioengineering and biotechnology · 2019
    Review
  8. Article
  9. Review
  10. T Cells Going Innate.Trends in immunology · 2016
    Review
  11. Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  12. T-cell exhaustion in allograft rejection and tolerance.Current opinion in organ transplantation · 2015
    Review
  13. Memory T Cell Migration.Frontiers in immunology · 2015
    Review
  14. Article
  15. Memory T Cells in Transplantation.Current transplantation reports · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Xian C LiDepartment of Surgery, the Methodist Hospital and Transplant Immunology Program, Methodist Hospital Research Institute, Texas Medical Center, Houston, TX 77030, USA. xcli@tmhs.org
Malgosia Kloc
Rafik M Ghobrial
Texas Medical Center · USHouston Methodist · US

Funding

Mechanisms of OX40 in peripheral transplant toleranceR01AI070315 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI LI, XIAN CHANG · 2007 to 2011
$1.7M
NIAID NIH HHS R01 AI070315
6 · The paper itself

Abstract

purpose of reviewMemory T cells present a different set of challenges to transplant patients; they are needed for protection against invading pathogens, especially under conditions of immunosuppression. But their presence also threatens transplant survival, as some of them are alloreactive. Efforts to resolve this paradox will be critical in the induction of transplant tolerance. RECENT

findingsThere has been significant progress made in the past few years in the areas of population diversity of memory T cells, metabolic control of their induction, and mechanisms and pathways involved in memory cell exhaustion. Multiple targets on memory T cells have been identified, some of which are under vigorous testing in various transplant models. SUMMARY: Memory T cells are both friends and foes to transplant patients, and tolerance strategies should selectively target alloreactive memory T cells and leave other memory cells unaltered. This situation remains a major challenge in the clinic.

Indexed as

AnimalsHumansImmune ToleranceImmunologic MemoryT-LymphocytesTransplantation Tolerance

Identifiers

PMID23838642
PMCPMC4264634
OpenAlexW1983315434

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.