ArticleBMJ (Clinical research ed.)2013
Mediators of the association between pre-eclampsia and cerebral palsy: population based cohort study.
Article in BMJ (Clinical research ed.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 84 citations in OpenAlex.
- A sibling study of the prenatal and perinatal risks for cerebral palsy.Pediatric research · 2025Article
- Mediating role of preterm birth in the relationship between maternal disease and infant development.BMC pregnancy and childbirth · 2025Article
- Maternal Hypertension and Adverse Neurodevelopment in a Cohort of Preterm Infants.JAMA network open · 2025Article
- Early-onset preeclampsia/gestational hypertension may be associated with a low incidence of cerebral palsy at 3 years old in singleton very low-birth-weight infants born at 28-31 weeks of gestation (EOPE-DQ study): a multi-center retrospective cohort study in 2013-2016.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Approaching the paradoxical relationship between hypertensive disorders of pregnancy and cerebral palsy among infants born very preterm with very low birth weight.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Immune imbalance mediates the relationship between plasma vitamin D concentration and preeclampsia in Chinese pregnant women: a case-control study.Frontiers in nutrition · 2025Article
- Chronic Inflammation Offers Hints About Viable Therapeutic Targets for Preeclampsia and Potentially Related Offspring Sequelae.International journal of molecular sciences · 2024Review
- Impacts of Maternal Preeclampsia Exposure on Offspring Neuronal Development: Recent Insights and Interventional Approaches.International journal of molecular sciences · 2024Review
- Neurodevelopmental Disruptions in Children of Preeclamptic Mothers: Pathophysiological Mechanisms and Consequences.International journal of molecular sciences · 2024Review
- Pre-pregnancy and pregnancy disorders, pre-term birth and the risk of cerebral palsy: a population-based study.International journal of epidemiology · 2023Article
- Gestational Antibodies to C. pneumoniae, H. pylori and CMV in Women with Preeclampsia and in Matched Controls.Maternal and child health journal · 2022Article
- Acute histologic chorioamnionitis independently and directly increases the risk for brain abnormalities seen on magnetic resonance imaging in very preterm infants.American journal of obstetrics and gynecology · 2022Article
- A review of infant growth and psychomotor developmental outcomes after intrauterine exposure to preeclampsia.BMC pediatrics · 2022Review
- Preeclampsia and Cerebral Palsy in Offspring.Children (Basel, Switzerland) · 2022Review
- The Global Pregnancy Collaboration (CoLab) symposium on short- and long-term outcomes in offspring whose mothers had preeclampsia: A scoping review of clinical evidence.Frontiers in medicine · 2022Article
- Preeclampsia and Neurodevelopmental Outcomes: Potential Pathogenic Roles for Inflammation and Oxidative Stress?Molecular neurobiology · 2021Review
- Mortality and neurological outcomes in extremely and very preterm infants born to mothers with hypertensive disorders of pregnancy.Scientific reports · 2021Article
- Association of Preeclampsia in Term Births With Neurodevelopmental Disorders in Offspring.JAMA psychiatry · 2020Article
- Neurodevelopmental Outcomes of Prenatal Preeclampsia Exposure.Trends in neurosciences · 2020Review
- Long non‑coding RNA NR_002794 is upregulated in pre‑eclampsia and regulates the proliferation, apoptosis and invasion of trophoblast cells.Molecular medicine reports · 2019Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo test the hypothesis that pre-eclampsia is a risk factor for cerebral palsy mediated through preterm birth and being born small for gestational age.
designPopulation based cohort study.
settingClinical data from the Norwegian Cerebral Palsy Registry were linked with perinatal data prospectively recorded by the Medical Birth Registry of Norway.
participantsAll singleton babies who survived the neonatal period during 1996-2006 (849 children with cerebral palsy and 616,658 control children).
main outcome measuresCerebral palsy and cerebral palsy subtypes.
resultsChildren exposed to pre-eclampsia had an excess risk of cerebral palsy (unadjusted odds ratio 2.5, 95% confidence interval 2.0 to 3.2) compared with unexposed children. Among children born at term (≥ 37 weeks), exposure to pre-eclampsia was not associated with an excess risk of cerebral palsy in babies not born small for gestational age (1.2, 0.7 to 2.0), whereas children exposed to pre-eclampsia and born small for gestational age had a significantly increased risk of cerebral palsy (3.2, 1.5 to 6.7). Non-small for gestational age babies born very preterm (<32 weeks) and exposed to pre-eclampsia had a reduced risk of cerebral palsy compared with unexposed children born at the same gestational age (0.5, 0.3 to 0.8), although the risk was not statistically significantly reduced among children exposed to pre-eclampsia and born small for gestational age (0.7, 0.4 to 1.3). Exposure to pre-eclampsia was not associated with a specific cerebral palsy subtype.
conclusionsExposure to pre-eclampsia was associated with an increased risk of cerebral palsy, and this association was mediated through the children being born preterm or small for gestational age, or both. Among children born at term, pre-eclampsia was a risk factor for cerebral palsy only when the children were small for gestational age.
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