ArticleExperimental eye research2013
Photopic visual input is necessary for emmetropization in mice.
Article in Experimental eye research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Light intensity and light/dark cycles regulate refractive development and myopia in mice through circadian rhythm-related genes.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Associations Among the Gradient Refractive Index of the Lens, Axial Length, and Refractive State in the Developing Murine Eye.Investigative ophthalmology & visual science · 2026Article
- IMI: The Role of Light in Refractive Development and Myopia: Evidence from Animal and Human Studies.Investigative ophthalmology & visual science · 2025Review
- Comparative analysis of ocular biometrics using spectral domain optical coherence tomography with Purkinje image and optic nerve head alignments in mice.European journal of medical research · 2025Article
- Insights into Myopia from Mouse Models.Annual review of vision science · 2024Review
- Blue Light Exposure: Ocular Hazards and Prevention-A Narrative Review.Ophthalmology and therapy · 2023Review
- A review of the effect of the light environment of the VDT workspace on the "learning to learn" effect of video game training.Frontiers in neuroscience · 2023Review
- Short-Term Exposure to Violet Light Emitted from Eyeglass Frames in Myopic Children: A Randomized Pilot Clinical Trial.Journal of clinical medicine · 2022Article
- Temporal properties of positive and negative defocus on emmetropization.Scientific reports · 2022Article
- RNA-sequencing analysis reveals the long noncoding RNA profile in the mouse myopic retina.Frontiers in genetics · 2022Article
- Genome-wide analysis of retinal transcriptome reveals common genetic network underlying perception of contrast and optical defocus detection.BMC medical genomics · 2021Article
- Ambient Light Regulates Retinal Dopamine Signaling and Myopia Susceptibility.Investigative ophthalmology & visual science · 2021Article
- Axial Length and Prevalence of Myopia among Schoolchildren in the Equatorial Region of Brazil.Journal of clinical medicine · 2020Article
- Three-dimensional data capture and analysis of intact eye lenses evidences emmetropia-associated changes in epithelial cell organization.Scientific reports · 2020Article
- Analysis of genetic networks regulating refractive eye development in collaborative cross progenitor strain mice reveals new genes and pathways underlying human myopia.BMC medical genomics · 2019Article
- Lack of cone mediated retinal function increases susceptibility to form-deprivation myopia in mice.Experimental eye research · 2019Article
- IMI - Report on Experimental Models of Emmetropization and Myopia.Investigative ophthalmology & visual science · 2019Review
- Violet Light Transmission is Related to Myopia Progression in Adult High Myopia.Scientific reports · 2017Article
- Article
- APLP2 Regulates Refractive Error and Myopia Development in Mice and Humans.PLoS genetics · 2015Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
It was recently demonstrated that refractive errors in mice stabilize around emmetropic values during early postnatal development, and that they develop experimental myopia in response to both visual form deprivation and imposed optical defocus similar to other vertebrate species. Animal studies also suggest that photopic vision plays critical role in emmetropization in diurnal species; however, it is unknown whether refractive eye development is guided by photopic vision in the mouse, which is a nocturnal species. We used an infrared mouse photorefractor and a high-resolution MRI to clarify the role of photopic visual input in refractive eye development in the mouse. Refractive eye development and form-deprivation myopia in P21-P89 C57BL/6J mice were analyzed under 12:12 h light-dark cycle, constant light and constant darkness regimens. Animals in all experimental groups were myopic at P21 (-13.2 ± 1.6 D, light-dark cycle; -12.5 ± 0.9 D, constant light; -12.5 ± 2.0 D, constant dark). The mean refractive error in the light-dark-cycle-reared animals was -0.5 ± 1.3 D at P32 and, and did not change significantly until P40 (+0.3 ± 0.6 D, P40). Animals in this group became progressively hyperopic between P40 and P89 (+2.2 ± 0.6 D, P67; +3.7 ± 2.0 D, P89). The mean refractive error in the constant-light-reared mice was -1.0 ± 0.7 D at P32 and remained stable until P89 (+0.1 ± 0.6 D, P40; +0.3 ± 0.6 D, P67; 0.0 ± 0.4 D, P89). Dark-reared animals exhibited highly hyperopic refractive errors at P32 (+5.2 ± 1.8 D) and became progressively more hyperopic with age (+8.7 ± 1.9 D, P40; +11.2 ± 1.4 D, P67). MRI analysis revealed that emmetropization in the P40-P89 constant-light-reared animals was associated with larger eyes, a longer axial length and a larger vitreous chamber compared to the light-dark-cycle-reared mice. Constant-light-reared mice also developed 4 times higher degrees of form-deprivation myopia on average compared to light-dark-cycle-reared animals (-12.0 ± 1.4 D, constant light; -2.7 ± 0.7 D, light-dark cycle). Dark-rearing completely prevented the development of form-deprivation myopia (-0.3 ± 0.5 D). Thus, photopic vision plays important role in normal refractive eye development and ocular response to visual form deprivation in the mouse.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.