ReviewEnvironmental health perspectives2013
Human Health Risk Assessment (HHRA) for environmental development and transfer of antibiotic resistance.
Review in Environmental health perspectives, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
162 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Antibiotic resistance genes circulating in Nigeria: a systematic review and meta-analysis from the One Health perspective.BMC medical genomics · 2025Pooled it
- Metagenome meta-analysis reveals an increase in the abundance of some multidrug efflux pumps and mobile genetic elements in chemically polluted environments.Applied and environmental microbiology · 2023Pooled it
- Antimicrobial resistance in fish and poultry: Public health implications for animal source food production in Nigeria, Egypt, and South Africa.Frontiers in antibiotics · 2022Pooled it
- Does Irrigation with Treated and Untreated Wastewater Increase Antimicrobial Resistance in Soil and Water: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Human health risk and remedial goal assessment using Monte Carlo simulation: a case study of arsenic contaminated allotment gardens in southern Poland.Environmental geochemistry and health · 2026Article
- Patterns of antimicrobial resistance genes in pathogens across One Health sectors in Ireland: anMicrobiology spectrum · 2026Article
- Transmission, Health Risks and Attenuation Strategies of Antibiotic Resistance Genes in Soil-Plant Systems.Environment & health (Washington, D.C.) · 2026Review
- Advancements in microalgae-mediated technologies for antibiotic removal from wastewater: a review.Biodegradation · 2026Review
- Metagenomic analysis of antimicrobial resistance, virulence, and mobile genetic elements in the gut microbiota of Caprinae species.Communications biology · 2026Article
- Quantitative microbial risk assessment of antibiotic resistance genes and mobile genetic elements in orchard soils across South Korea.Applied and environmental microbiology · 2026Article
- Metals and Microbes: Microbial Community Diversity and Antibiotic Resistance in the Animas River Watershed, Colorado, USA.Microorganisms · 2026Article
- Leveraging whole-genome sequencing for microbial contamination tracking and risk assessment in pharmaceutical manufacturing.Frontiers in microbiology · 2026Article
- 'Mind the gaps': stakeholder perspectives on addressing antimicrobial resistance in the environment in the Indian context.Global health action · 2025Article
- The Microbial Trojan Horse and Antimicrobial Resistance: Acanthamoeba as an Environmental Reservoir for Multidrug Resistant Bacteria.Environmental microbiology · 2025Article
- City or Suburb, Resistance Flows: Wastewater-BorneAntibiotics (Basel, Switzerland) · 2025Article
- The Role of Water as a Reservoir for Antibiotic-Resistant Bacteria.Antibiotics (Basel, Switzerland) · 2025Review
- Invisible Engines of Resistance: How Global Inequities Drive Antimicrobial Failure.Antibiotics (Basel, Switzerland) · 2025Review
- Corrigendum to "Multidrug resistance from a one health perspective in Ethiopia: a systematic review and meta-analysis of literatures (2015-2020)" [One Health 14(2022) 1-12/100390].One health (Amsterdam, Netherlands) · 2025Article
- A Scoping Review Unveiling Antimicrobial Resistance Patterns in the Environment of Dairy Farms Across Asia.Antibiotics (Basel, Switzerland) · 2025Review
- Agriculturally Sourced Multidrug-ResistantPathogens (Basel, Switzerland) · 2025Article
102 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOnly recently has the environment been clearly implicated in the risk of antibiotic resistance to clinical outcome, but to date there have been few documented approaches to formally assess these risks.
objectiveWe examined possible approaches and sought to identify research needs to enable human health risk assessments (HHRA) that focus on the role of the environment in the failure of antibiotic treatment caused by antibiotic-resistant pathogens.
methodsThe authors participated in a workshop held 4-8 March 2012 in Québec, Canada, to define the scope and objectives of an environmental assessment of antibiotic-resistance risks to human health. We focused on key elements of environmental-resistance-development "hot spots," exposure assessment (unrelated to food), and dose response to characterize risks that may improve antibiotic-resistance management options. DISCUSSION: Various novel aspects to traditional risk assessments were identified to enable an assessment of environmental antibiotic resistance. These include a) accounting for an added selective pressure on the environmental resistome that, over time, allows for development of antibiotic-resistant bacteria (ARB); b) identifying and describing rates of horizontal gene transfer (HGT) in the relevant environmental "hot spot" compartments; and c) modifying traditional dose-response approaches to address doses of ARB for various health outcomes and pathways.
conclusionsWe propose that environmental aspects of antibiotic-resistance development be included in the processes of any HHRA addressing ARB. Because of limited available data, a multicriteria decision analysis approach would be a useful way to undertake an HHRA of environmental antibiotic resistance that informs risk managers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.