Evidence map›Paper›PMID 23838109›Full record

SynthesisCirculation. Cardiovascular quality and outcomes2013

Cognitive change in heart failure: a systematic review.

Alexandra M Hajduk, Catarina I Kiefe, Sharina D Person, Joel G Gore, Jane S Saczynski

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Circulation. Cardiovascular quality and outcomes, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Association of religiosity and spirituality with quality of life in patients with cardiovascular disease: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2018
    Pooled it
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  9. Trial
  10. Heart Meets Brain: Insights into Neurocardiac Pathophysiology.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Determinants of cognitive health in the elderly: a comprehensive analysis of demographics, health status, and lifestyle factors from NHANES.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  17. Article
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  19. Article
  20. Review

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alexandra M HajdukDepartment of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA 01655, USA. alexandra.hajduk@umassmed.edu
Catarina I Kiefe
Sharina D Person
Joel G Gore
Jane S Saczynski

Funding

TRACE-COREU01HL105268 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KIEFE, CATARINA I. · 2010 to 2013
$5.8M
Medical Illness & Cognitive Impairment in Older Adults: Heart Failure as a ModelK01AG033643 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SACZYNSKI, JANE STEELE · 2010 to 2014
$628k
NCRR NIH HHS U54RR026088NHLBI NIH HHS U01 HL105268NHLBI NIH HHS U01HL105268-01NIA NIH HHS K01 AG033643NIA NIH HHS K01AG033643
6 · The paper itself

Abstract

backgroundCognitive impairment, highly prevalent in patients with heart failure (HF), increases risk for hospitalization and mortality. However, the course of cognitive change in HF is not well characterized. The purpose of this systematic review was to examine the available evidence longitudinal changes in cognitive function in patients with HF. METHODS AND

resultsA literature search of several electronic databases was performed. Studies published from January 1, 1980, to September 30, 2012, that used validated measures to diagnose HF and assess cognitive function ≥2× in adults with HF were eligible for inclusion. Change in cognitive function was examined in the context of HF treatments applied (eg, medication initiation, left ventricular assist device implantation), length of follow-up, and comparison group. Fifteen studies met eligibility criteria. Significant decline in cognitive function was noted among patients with HF followed up for >1 year. Improvements in cognition were observed among patients with HF undergoing interventions to improve cardiac function (eg, heart transplantation) and among patients examined over short time periods (<1 year). Studies comparing patients' cognition over time with their own baseline tended to report improvements, whereas studies using a comparison group without HF tended to report declines or stability in cognition over time among patients with HF.

conclusionsPatients with HF are at increased risk for cognitive decline, but this risk seems to be modifiable with cardiac treatment. Further research is needed to identify the mechanisms that cause cognitive changes in HF.

Indexed as

CognitionCognition DisordersHeart FailureHumansRecovery of FunctionRisk FactorsTime FactorsTreatment Outcomecognitionepidemiologyheart failure

Identifiers

PMID23838109
PMCPMC3872030

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.