ReviewInternational journal of experimental pathology2013
Synthetic and degradable patches: an emerging solution for rotator cuff repair.
Review in International journal of experimental pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Biologic augmentation in rotator cuff repair: current evidence and future directions.JSES reviews, reports, and techniques · 2026Review
- Rotator cuff repair and biologic augmentation-what do we know?JSES reviews, reports, and techniques · 2026Review
- Macrophage polarisation under immune regulation as a therapeutic target for tendon-bone healing: multifactorial regulation and mechanistic insights.Frontiers in immunology · 2026Review
- Advanced bioactive materials and strategies for tendon repair and function restoration.Journal of orthopaedic translation · 2025Review
- Augmentation Techniques for Rotator Cuff Repairs.JBJS reviews · 2025Review
- Biological Augmentation Using Electrospun Constructs with Dual Growth Factor Release for Rotator Cuff Repair.ACS applied bio materials · 2025Article
- Decellularized tendon patch enhance biological and mechanical healing of large-to-massive rotator cuff tear in a rat chronic model: a comparison study of patch sterilization and storage methods.Journal of orthopaedic surgery and research · 2025Article
- Article
- Advances focusing on the application of decellularization methods in tendon-bone healing.Journal of advanced research · 2025Review
- Bioactive Patch for Rotator Cuff Repairing via Enhancing Tendon-to-Bone Healing: A Large Animal Study and Short-Term Outcome of a Clinical Trial.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Tendon-derived matrix crosslinking techniques for electrospun multi-layered scaffolds.Journal of biomedical materials research. Part A · 2023Article
- Exosomes from CD133Journal of orthopaedic translation · 2023Article
- NIR-II live imaging study on the degradation pattern of collagen in the mouse model.Regenerative biomaterials · 2023Article
- Scaffold-based tissue engineering strategies for soft-hard interface regeneration.Regenerative biomaterials · 2023Review
- A collagen/PLA hybrid scaffold supports tendon-derived cell growth for tendon repair and regeneration.Journal of biomedical materials research. Part B, Applied biomaterials · 2022Article
- Clinical perspectives for repairing rotator cuff injuries with multi-tissue regenerative approaches.Journal of orthopaedic translation · 2022Review
- Evaluation of patches for rotator cuff repair: A systematic review and meta-analysis based on animal studies.Bioactive materials · 2022Article
- Biodegradation of poly(L-lactic acid) and poly(ε-caprolactone) patches by human amniotic fluid in an in-vitro simulated fetal environment.Scientific reports · 2022Article
- A bio-inductive collagen scaffold that supports human primary tendon-derived cell growth for rotator cuff repair.Journal of orthopaedic translation · 2021Article
- Use of biologics in rotator cuff disorders: Current concept review.Journal of clinical orthopaedics and trauma · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of rotator cuff augmentation has increased dramatically over the last 10 years in response to the high rate of failure observed after non-augmented surgery. However, although augmentations have been shown to reduce shoulder pain, there is no consensus or clear guideline as to what is the safest or most efficacious material. Current augmentations, either available commercially or in development, can be classified into three categories: non-degradable structures, extra cellular matrix (ECM)-based patches and degradable synthetic scaffolds. Non-degradable structures have excellent mechanical properties, but can cause problems of infection and loss of integrity in the long-term. ECM-based patches usually demonstrate excellent biological properties in vitro, but studies have highlighted complications in vivo due to poor mechanical support and to infection or inflammation. Degradable synthetic scaffolds represent the new generation of implants. It is proposed that a combination of good mechanical properties, active promotion of biological healing, low infection risk and bio-absorption are the ideal characteristics of an augmentation material. Among the materials with these features, those processed by electrospinning have shown great promis. However, their clinical effectiveness has yet to be proven and well conducted clinical trials are urgently required.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.