ReviewInternational journal of experimental pathology2013
Fatigue loading of tendon.
Review in International journal of experimental pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Pooled it
- Mechanical loading and fatigue-induced changes in triceps surae muscle-tendon unit: sex-specific responses and recovery dynamics.Frontiers in physiology · 2026Article
- Fascicular Elastin Impacts Tendon-Specific Ramp-to-Failure and Fatigue Mechanics.Journal of biomechanical engineering · 2025Article
- Shear wave propagation as a noninvasive metric of loading and microdamage in tendon fascicles.Journal of the mechanical behavior of biomedical materials · 2025Article
- Materials and Structures Inspired by Human Heel Pads for Advanced Biomechanical Function.Biomimetics (Basel, Switzerland) · 2025Review
- Tissue-engineered mesenchymal stem cell constructs alleviate tendinopathy by suppressing vascularization.Bioactive materials · 2024Article
- Modeling fatigue failure in soft tissue using a visco-hyperelastic model with discontinuous damage.Journal of the mechanical behavior of biomedical materials · 2023Article
- Measuring Local Tissue Strains in Tendons via Open-Source Digital Image Correlation.Journal of visualized experiments : JoVE · 2023Article
- Rehydration of the Tendon Fascicle Bundles Using Simulated Body Fluid Ensures Stable Mechanical Properties of the Samples.Materials (Basel, Switzerland) · 2022Article
- The impaired healing hypothesis: a mechanism by which psychosocial stress and personal characteristics increase MSD risk?Ergonomics · 2022Article
- Tensile fatigue strength and endurance limit of human meniscus.Journal of the mechanical behavior of biomedical materials · 2022Article
- The Functions and Mechanisms of Low-Level Laser Therapy in Tendon Repair (Review).Frontiers in physiology · 2022Article
- Tendinopathy and tendon material response to load: What we can learn from small animal studies.Acta biomaterialia · 2021Review
- Accumulation of collagen molecular unfolding is the mechanism of cyclic fatigue damage and failure in collagenous tissues.Science advances · 2020Article
- Article
- Biplanar ultrasound investigation ofTranslational sports medicine · 2019Article
- Patellar Tendon Strain Associates to Tendon Structural Abnormalities in Adolescent Athletes.Frontiers in physiology · 2019Article
- Supraspinatus Tendons Have Different Mechanical Properties Across Sex.Journal of biomechanical engineering · 2019Article
- Accelerometer-based prediction of running injury in National Collegiate Athletic Association track athletes.Journal of biomechanics · 2018Article
- Fatigue loading of tendon results in collagen kinking and denaturation but does not change local tissue mechanics.Journal of biomechanics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Tendon injuries, often called tendinopathies, are debilitating and painful conditions, generally considered to develop as a result of tendon overuse. The aetiology of tendinopathy remains poorly understood, and whilst tendon biopsies have provided some information concerning tendon appearance in late-stage disease, there is still little information concerning the mechanical and cellular events associated with disease initiation and progression. Investigating this in situ is challenging, and numerous models have been developed to investigate how overuse may generate tendon fatigue damage and how this may relate to tendinopathy conditions. This article aims to review these models and our current understanding of tendon fatigue damage. We review the strengths and limitations of different methodologies for characterizing tendon fatigue, considering in vitro methods that adopt both viable and non-viable samples, as well as the range of different in vivo approaches. By comparing data across model systems, we review the current understanding of fatigue damage development. Additionally, we compare these findings with data from tendinopathic tissue biopsies to provide some insights into how these models may relate to the aetiology of tendinopathy. Fatigue-induced damage consistently highlights the same microstructural, biological and mechanical changes to the tendon across all model systems and also correlates well with the findings from tendinopathic biopsy tissue. The multiple testing routes support matrix damage as an important contributor to tendinopathic conditions, but cellular responses to fatigue appear complex and often contradictory.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.