Evidence map›Paper›PMID 23837178›Full record

ReviewPediatrics2013

Strategies for more rapid translation of cellular therapies for children: a US perspective.

Rosa Sanchez, Leslie E Silberstein, Robert W Lindblad, Lisbeth A Welniak, Traci Heath Mondoro, John E Wagner

Abstract readReview
In one paragraph

Review in Pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rosa SanchezBlood Systems Research Institute, San Francisco, California, USA. rosasanchez.rosen@gmail.com
Leslie E Silberstein
Robert W Lindblad
Lisbeth A Welniak
Traci Heath Mondoro
John E Wagner

Funding

Trial Design and Biostatistical Support CoreP01CA065493 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI John E. Wagner · 1995 to 2026
$48.2M
A Multidisciplinary Approach to Education in Pediatric Transfusion MedicineK07HL088923 · NHLBI · VITALANT · PI SANCHEZ ROSEN, ROSA · 2007 to 2011
$594k
NCI NIH HHS P01 CA065493NHLBI NIH HHS K07 HL088923NHLBI NIH HHS N01 HB07197NHLBI NIH HHS N01 HB 07200
6 · The paper itself

Abstract

Clinical trials for pediatric diseases face many challenges, including trial design, accrual, ethical considerations for children as research subjects, and the cost of long-term follow-up studies. In September 2011, the Production Assistance for Cellular Therapies Program, funded by the National Heart, Lung, and Blood Institute of the National Institutes of Health, sponsored a workshop, "Cell Therapy for Pediatric Diseases: A Growing Frontier," with the overarching goal of optimizing the path of discovery in research involving novel cellular therapeutic interventions for debilitating pediatric conditions with few or no available treatment options. Academic and industry investigators in the fields of cellular therapy and regenerative medicine described the obstacles encountered in conducting a clinical trial from concept to conclusion. Patient and parent advocates, bioethicists, biostatisticians, regulatory representatives from the US Food and Drug Administration, and translational scientists actively participated in this workshop, seeking to identify the unmet needs specific to cellular therapies and treatment of pediatric diseases and propose strategies to facilitate the development of novel therapies. In this article we summarize the obstacles and potential corrective strategies identified by workshop participants to maximize the speed of cell therapy translational research for childhood diseases.

Indexed as

Cell- and Tissue-Based TherapyTranslational Research, BiomedicalChildClinical Trials as TopicCooperative BehaviorDiffusion of InnovationEducationHealth Services AccessibilityHumansInterdisciplinary CommunicationNeeds AssessmentUnited Statescell therapypediatric clinical trialsstem cell

Identifiers

PMID23837178
PMCPMC3727672

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.