ArticleJournal of periodontal & implant science2013
Epigenetic biomarkers: a step forward for understanding periodontitis.
Article in Journal of periodontal & implant science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 54 citations in OpenAlex.
- Supra- and sub-gingival instrumentation of periodontitis with the adjunctive treatment of a chloramine - a one-year randomized clinical trial study.Acta odontologica Scandinavica · 2024Trial
- Epigenetic regulation of inflammation in localized aggressive periodontitis.Clinical epigenetics · 2017Trial
- EGCG Regulates the Effect of HDAC6 on Oxidative Stress of Human Periodontal Ligament Fibroblasts Induced by Lipopolysaccharide.Immunity, inflammation and disease · 2025Article
- The dual role of IL-17 in periodontitis regulating immunity and bone homeostasis.Frontiers in immunology · 2025Review
- Regulatory mechanisms of GCN5 in osteogenic differentiation of MSCs in periodontitis.Clinical and experimental dental research · 2023Review
- Periodontitis as a risk factor for head and neck cancer.Medicina oral, patologia oral y cirugia bucal · 2021Review
- Current advances of epigenetics in periodontology from ENCODE project: a review and future perspectives.Clinical epigenetics · 2021Review
- Decitabine Inhibits Bone Resorption in Periodontitis by Upregulating Anti-Inflammatory Cytokines and Suppressing Osteoclastogenesis.Biomedicines · 2021Article
- Histone Methylation: Achilles Heel and Powerful Mediator of Periodontal Homeostasis.Journal of dental research · 2020Article
- The role of inflammation and genetics in periodontal disease.Periodontology 2000 · 2020Review
- [Effect of histone acetylation on osteogenic differentiation of periodontal ligament stem cells derived from periodontitis tissue].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2019Review
- Oral health in geroscience: animal models and the aging oral cavity.GeroScience · 2018Review
- [Therapeutic effect of enhancer of Zeste homolog 2 inhibitor GSK343 on periodontitis by regulating macrophage differentiation].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2017Article
- Epigenetic regulation in dental pulp inflammation.Oral diseases · 2017Review
- Epigenetics and Periodontitis: A Contemporary Review.Journal of clinical and diagnostic research : JCDR · 2016Review
- Role of epigenetics in modulation of immune response at the junction of host-pathogen interaction and danger molecule signaling.Pathogens and disease · 2016Article
- Epigenetics: general characteristics and implications for oral health.Restorative dentistry & endodontics · 2015Review
- The inflammophilic character of the periodontitis-associated microbiota.Molecular oral microbiology · 2014Review
- Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response.Trends in immunology · 2014Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontitis is a common oral disease that is characterized by infection and inflammation of the tooth supporting tissues. While its incidence is highly associated with outgrowth of the pathogenic microbiome, some patients show signs of predisposition and quickly fall into recurrence after treatment. Recent research using genetic associations of candidates as well as genome-wide analysis highlights that variations in genes related to the inflammatory response are associated with an increased risk of periodontitis. Intriguingly, some of the genes are regulated by epigenetic modifications, supposedly established and reprogrammed in response to environmental stimuli. In addition, the treatment with epigenetic drugs improves treatment of periodontitis in a mouse model. In this review, we highlight some of the recent progress identifying genetic factors associated with periodontitis and point to promising approaches in epigenetic research that may contribute to the understanding of molecular mechanisms involving different responses in individuals and the early detection of predispositions that may guide in future oral treatment and disease prevention.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.