ArticleOncoTargets and therapy2013
Apoptosis and G2/M arrest induced by Allium ursinum (ramson) watery extract in an AGS gastric cancer cell line.
Article in OncoTargets and therapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed.
- Review
- The Antioxidant, Antimicrobial, and Antitumor Proprieties of Flavonol-Rich Extracts fromInternational journal of molecular sciences · 2024Article
- Review
- Techno-Functional Properties of Burgers Fortified by Wild Garlic Extract: A Reconsideration.Foods (Basel, Switzerland) · 2023Article
- The Regulation of Cyclins and Cyclin-Dependent Kinases in the Development of Gastric Cancer.International journal of molecular sciences · 2023Review
- Phytochemical Characterization and Screening of Antioxidant, Antimicrobial and Antiproliferative Properties ofPlants (Basel, Switzerland) · 2021Article
- Pinocembrin Inhibits the Proliferation and Metastasis of Breast CancerFrontiers in oncology · 2021Article
- Phytochemicals for the Prevention and Treatment of Gastric Cancer: Effects and Mechanisms.International journal of molecular sciences · 2020Review
- Antioxidant and Antiproliferative Activity ofFrontiers in microbiology · 2020Article
- Ethanol extracts ofFood & nutrition research · 2019Article
- Tulbaghia violacea and Allium ursinum Extracts Exhibit Anti-Parasitic and Antimicrobial Activities.Molecules (Basel, Switzerland) · 2018Article
- Anti-Tumor Effects of Atractylenolide-I on Human Ovarian Cancer Cells.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe present study was designed to determine whether Allium ursinum L (ramson) could inhibit the proliferation of human AGS gastric cancer cells. Furthermore, we attempted to determine whether this inhibition could occur by targeting regulatory elements of the cell cycle.
methodsFlow cytometry was used to observe apoptosis and the cell cycle in AGS cell lines treated or not treated with ramson watery extract. Proteins related to the cell cycle were detected by Western blotting. Caspase activity was measured using a colorimetric assay kit according to the manufacturer's instructions.
resultsRamson watery extract induced apoptosis and G2/M phase arrest in AGS cells. Western blotting showed that cyclin B was inhibited by ramson watery extract. However, G1 phase-related proteins remain unchanged after treatment.
conclusionOur results indicate that ramson effectively sup pressed proliferation and induced apoptosis and G2/M arrest in AGS cells by regulating elements of the cell cycle.
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