ArticleThe Journal of cell biology2013
Mitotic phosphorylation of Exo84 disrupts exocyst assembly and arrests cell growth.
Article in The Journal of cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- Emerging Roles of Exocyst Complex in Fungi: A Review.Journal of fungi (Basel, Switzerland) · 2024Review
- A novel nonsense variant in EXOC8 underlies a neurodevelopmental disorder.Neurogenetics · 2022Article
- Incompatibility between proliferation and plant invasion is mediated by a regulator of appressorium formation in the corn smut fungusProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Integrative structure and function of the yeast exocyst complex.Protein science : a publication of the Protein Society · 2020Article
- Regulation of Exocyst Function in Pollen Tube Growth by Phosphorylation of Exocyst Subunit EXO70C2.Frontiers in plant science · 2020Article
- Sphingolipids are required for exocyst polarity and exocytic secretion inCell & bioscience · 2020Article
- Cyclin-dependent kinase-mediated phosphorylation of the exocyst subunit Exo84 in late GThe Journal of biological chemistry · 2019Article
- Spatial and Translational Regulation of Exocyst Subunits by Cell Cycle in Budding Yeast.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Exposing the Elusive Exocyst Structure.Trends in biochemical sciences · 2018Review
- Cell polarity protein Spa2 coordinates Chs2 incorporation at the division site in budding yeast.PLoS genetics · 2018Article
- Cryo-EM structure of the exocyst complex.Nature structural & molecular biology · 2018Article
- Polarized Exocytosis.Cold Spring Harbor perspectives in biology · 2017Review
- Cell cycle-dependent phosphorylation of Sec4p controls membrane deposition during cytokinesis.The Journal of cell biology · 2016Article
- The Exocyst at a Glance.Journal of cell science · 2015Review
- How PI3K-derived lipids control cell division.Frontiers in cell and developmental biology · 2015Review
- The role of Sec3p in secretory vesicle targeting and exocyst complex assembly.Molecular biology of the cell · 2014Article
- In Candida albicans, phosphorylation of Exo84 by Cdk1-Hgc1 is necessary for efficient hyphal extension.Molecular biology of the cell · 2014Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
The rate of eukaryotic cell growth is tightly controlled for proper progression through each cell cycle stage and is important for cell size homeostasis. It was previously shown that cell growth is inhibited during mitosis when cells are preparing for division. However, the mechanism for growth arrest at this stage is unknown. Here we demonstrate that exocytosis of a select group of cargoes was inhibited before the metaphase-anaphase transition in the budding yeast Saccharomyces cerevisiae. The cyclin-dependent kinase, Cdk1, when bound to the mitotic cyclin Clb2, directly phosphorylated Exo84, a component of the exocyst complex essential for exocytosis. Mitotic phosphorylation of Exo84 disrupted the assembly of the exocyst complex, thereby affecting exocytosis and cell surface expansion. Our study demonstrates the coordination between membrane trafficking and cell cycle progression and provides a molecular mechanism by which cell growth is controlled during the cell division cycle.
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