ArticleThe Journal of biological chemistry2013
The transcription factor Atonal homolog 8 regulates Gata4 and Friend of Gata-2 during vertebrate development.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Gene networks and the evolution of olfactory organs, eyes, hair cells and motoneurons: a view encompassing lancelets, tunicates and vertebrates.Frontiers in cell and developmental biology · 2024Review
- Vision and retina evolution: How to develop a retina.IBRO neuroscience reports · 2022Article
- Atoh8 in Development and Disease.Biology · 2022Review
- atoh8 expression pattern in early zebrafish embryonic development.Histochemistry and cell biology · 2021Article
- In focus in HCB.Histochemistry and cell biology · 2021Article
- Targeted deletion of Atoh8 results in severe hearing loss in mice.Genesis (New York, N.Y. : 2000) · 2021Article
- PRC2 Regulated Atoh8 Is a Regulator of Intestinal Microfold Cell (M Cell) Differentiation.International journal of molecular sciences · 2021Article
- A novel isoform of ATOH8 promotes the metastasis of breast cancer by regulating RhoC.Journal of molecular cell biology · 2021Article
- BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts.Bone research · 2020Article
- The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension.Science signaling · 2019Article
- Article
- Neurod1 Is Essential for the Primary Tonotopic Organization and Related Auditory Information Processing in the Midbrain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Atoh8 acts as a regulator of chondrocyte proliferation and differentiation in endochondral bones.PloS one · 2019Article
- Murine transcription factor Math6 is a regulator of placenta development.Scientific reports · 2018Article
- Calcineurin signaling in the heart: The importance of time and place.Journal of molecular and cellular cardiology · 2017Review
- Article
- Downregulation of ATOH8 induced by EBV-encoded LMP1 contributes to the malignant phenotype of nasopharyngeal carcinoma.Oncotarget · 2016Article
- Generation of a Conditional Allele of the Transcription Factor Atonal Homolog 8 (Atoh8).PloS one · 2016Article
- A novel interaction between ATOH8 and PPP3CB.Histochemistry and cell biology · 2016Article
- Spatiotemporal expression of Math6 during mouse embryonic development.Histochemistry and cell biology · 2015Article
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Authors and funding
13 authors at 6 institutions in 5 countries.
Funding
Abstract
GATA and Friend of GATA (FOG) form a transcriptional complex that plays a key role in cardiovascular development in both fish and mammals. In the present study we demonstrate that the basic helix-loop-helix transcription factor Atonal homolog 8 (Atoh8) is required for development of the heart in fish but not in mice. Genetic studies reveal that Atoh8 interacts specifically with Gata4 and Fog1 during development of the heart and swim bladder in the fish. Biochemical studies reveal that ATOH8, GATA4, and FOG2 associate in a single complex in vitro. In contrast to fish, ATOH8-deficient mice exhibit normal cardiac development and loss of ATOH8 does not alter cardiac development in Gata4(+/-) mice. This species difference in the role of ATOH8 is explained in part by LacZ and GFP reporter alleles that reveal restriction of Atoh8 expression to atrial but not ventricular myocardium in the mouse. Our findings identify ATOH8 as a novel regulator of GATA-FOG function that is required for cardiac development in the fish but not the mouse. Whether ATOH8 modulates GATA-FOG function at other sites or in more subtle ways in mammals is not yet known.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.