ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2014
Hypoperfusion and T1-hypointense lesions in white matter in multiple sclerosis.
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Impaired cerebrovascular reactivity is associated with disability and cognitive performance in relapsing-remitting multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Observational
- Automated characterization of the gray matter white matter distribution demonstrates age-related decline.Scientific reports · 2026Article
- From BBB to PPP: Bioenergetic requirements and challenges for oligodendrocytes in health and disease.Journal of neurochemistry · 2025Review
- The ageing central nervous system in multiple sclerosis: the imaging perspective.Brain : a journal of neurology · 2024Review
- Pathophysiology of multiple sclerosis damage and repair: Linking cerebral hypoperfusion to the development of irreversible tissue loss in multiple sclerosis using magnetic resonance imaging.European journal of neurology · 2023Article
- Characterizing the time course of cerebrovascular reactivity in multiple sclerosis.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022Article
- Correlation analysis between foveal avascular zone and near peripheral retinal hypoperfusion in multiple sclerosis: a wide field optical coherence tomography angiography study.Frontiers in medicine · 2022Article
- Article
- Detecting Small Vessel Pathology in Cocaine Use Disorder.Frontiers in neuroscience · 2021Article
- Detection of Active Plaques in Multiple Sclerosis using 3 and 12 Directional Diffusion-weighted Imaging: Comparison with Gadolinium-enhanced MR Imaging.Journal of biomedical physics & engineering · 2020Article
- Determination of Brain Metabolite TJournal of magnetic resonance imaging : JMRI · 2020Article
- Serum Neurofilament Light Chain Levels are Associated with Lower Thalamic Perfusion in Multiple Sclerosis.Diagnostics (Basel, Switzerland) · 2020Article
- Degree of microstructural changes within T1-SE versus T1-GE hypointense lesions in multiple sclerosis: relevance for the definition of "black holes".European radiology · 2020Article
- [European journal of nuclear medicine and molecular imaging · 2020Article
- Lower total cerebral arterial flow contributes to cognitive performance in multiple sclerosis patients.Multiple sclerosis (Houndmills, Basingstoke, England) · 2020Article
- Predicting Fazekas scores from automatic segmentations of white matter signal abnormalities.Aging · 2020Article
- Optical Coherence Tomography Angiography in Neurodegenerative Diseases: A Review.Eye and brain · 2020Review
- Number of MRI T1-hypointensity corrected by T2/FLAIR lesion volume indicates clinical severity in patients with multiple sclerosis.PloS one · 2020Article
- Time matters in multiple sclerosis: can early treatment and long-term follow-up ensure everyone benefits from the latest advances in multiple sclerosis?Journal of neurology, neurosurgery, and psychiatry · 2018Article
- What Have We Learned from Perfusion MRI in Multiple Sclerosis?AJNR. American journal of neuroradiology · 2018Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundLongitudinal magnetic resonance imaging (MRI) studies show that a fraction of the multiple sclerosis (MS) T2-lesions contain T1-hypointense components that may persist to represent severe, irreversible tissue damage. It is not known why certain lesions convert to persistent T1-hypointense lesions.
objectiveWe hypothesized that the T1-hypointense lesions disproportionately distribute in the more hypoperfused areas of the brain. Here we investigated the association between hypoperfusion and T1-hypointense lesion distributions.
methodsMRI and cerebral blood flow (CBF) data were acquired on 45 multiple sclerosis (MS) patients and 20 healthy controls. CBF maps were generated using pseudo-continuous arterial spin labeling technique. The lesion probability distribution maps were superimposed on the CBF maps.
resultsTwo distinct CBF clusters were observed in the white matter (WM) both in healthy controls and MS patients. An overall reduction in CBF was observed in MS patients compared to healthy controls. The majority of the T1-hypointense lesions were concentrated almost exclusively in the WM regions with lower CBF. The T2-hyperintense lesions were more generally distributed in both higher and lower perfused WM.
conclusionThis study suggests an association between hypoperfusion and T1-hypointense lesions.
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